比生群
中文名称 | 比生群 |
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中文同义词 | BISANTRENE(含有少量DMSO) (FREE BASE);9,10-蒽二甲醛双(4,5-二氢-1H-咪唑-2-基)腙;必桑那;咪蒽二腙;9,10-蒽二醛双[(4,5-二氢-1H-咪唑-2-基)腙];比生群;必桑郡;比索布啉 |
英文名称 | Bisantrene |
英文同义词 | BISANTRENE;BISANTRENE HCL;9,10-An-thracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-y1)hydrazone];9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone);9,10-Bis((2-(4,5-dihydro-1H-iMidazol-2-yl)hydrazono)Methyl)anthracene;Bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone)-9,10-anthracenedicarboxaldehyde dihydrochloride;ADAH;CL-216942 |
CAS号 | 78186-34-2 |
分子式 | C22H22N8 |
分子量 | 398.46 |
EINECS号 | |
相关类别 | 抗肿瘤药;其它抗肿瘤药物;药物 |
Mol文件 | 78186-34-2.mol |
结构式 |
比生群 性质
沸点 | 646.3±65.0 °C(Predicted) |
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密度 | 1.41±0.1 g/cm3(Predicted) |
储存条件 | Sealed in dry,Room Temperature |
溶解度 | 去离子水中的溶解度:8mg/mL |
酸度系数(pKa) | 9.78±0.10(Predicted) |
形态 | 固体 |
颜色 | 橙至红色 |
InChIKey | NJSMWLQOCQIOPE-OCHFTUDZSA-N |
SMILES | C1(/C=N/NC2=NCCN2)=C2C=CC=CC2=C(/C=N/NC2=NCCN2)C2C=CC=CC1=2 |
Topoisomerase II
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Bisantrene shows an outstanding ability to form a complex with DNA. Bisantrene exhibits the most effective binding (even neglecting electrostatic contacts), followed by the 9-substituted compounds and finally by 1-IHA. Bisantrene congeners retained a remarkable capacity for binding to the single-stranded structure. In comparison with the K i values found for double-stranded DNA, 9-IHA shows a 2-fold increase, 1-IHA maintains the same values, and aza-9-IHA exhibits a modest reduction. On the other hand, Bisantrene, although undergoing a 6-fold reduction in K i , still exhibits an affinity constant of the order of 10 6 M -1 . Bisantrene promots DNase I cleavage at oligopurine-oligopyrimidine tracts; conversely, it slightly reduces the cleavage activity at alternating purine-pyrimidine sequences. Bisantrene is an active new drug in the treatment of metastatic breast cancer. Bisantrene is an inhibitor of [ 3 H]uridine incorporation into RNA and [ 3 H]thymidine incorporation into DNA.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-100875 | Bisantrene | 5 mg | 365元 | |
2024/08/19 | HY-100875 | 比生群 Bisantrene | 78186-34-2 | 10mg | 550元 |