盐酸替莫普利
中文名称 | 盐酸替莫普利 |
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中文同义词 | [(2S,6R)-6-[[(S)-1-(乙氧羰基)-3-苯基丙基]氨基]-5-氧代-2-(2-噻吩基)-1,4-硫氮杂卓-4-基]乙酸盐酸盐;盐酸替莫普利;替莫普利盐酸盐;TEMOCAPRIL HYDROCHLORIDE盐;盐酸替莫普利及中间体;2-((2S,6R)-6-(((S)-1-乙氧基-1-氧代-4-苯基丁-2-基)氨基)-5-氧代-2-(噻吩-2-基)-1,4-硫氮杂环庚烷-4-基)乙酸盐酸盐;PERFEMIKER]盐酸替莫普利 |
英文名称 | Temocapril hydrochloride |
英文同义词 | TEMOCAPRIL HYDROCHLORIDE;Acecol;CS-622;1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI);1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]-;Temocapril Hcl;TemocarpileHCL;Temocarpilhydrochloride |
CAS号 | 110221-44-8 |
分子式 | C23H28N2O5S2.ClH |
分子量 | 513.076 |
EINECS号 | 1312995-182-4 |
相关类别 | 小分子抑制剂,天然产物;中间体;药物分子;原料;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors |
Mol文件 | 110221-44-8.mol |
结构式 |
盐酸替莫普利 性质
熔点 | 196-2000C (dec) |
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比旋光度 | 25D +47.7° (c = 1 in DMF) |
储存条件 | Inert atmosphere,Store in freezer, under -20°C |
溶解度 | DMF(微溶)、DMSO(微溶)、甲醇(微溶) |
形态 | 固体 |
颜色 | 白色至类白色 |
CAS 数据库 | 110221-44-8(CAS DataBase Reference) |
Target | Value |
ACE |
Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the human small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 in the liver.
Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney.
Animal Model: | Male Sprague Dawley rats |
Dosage: | 30 mg/kg |
Administration: | Oral administration, daily, for 4 weeks |
Result: | Suppressed the blood pressure elevation induced by Ang I. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-B0384 | 盐酸替莫普利 Temocapril hydrochloride | 110221-44-8 | 5 mg | 304元 |
2024/01/25 | HY-B0384 | 盐酸替莫普利 Temocapril hydrochloride | 110221-44-8 | 10mM * 1mLin DMSO | 343元 |