fluphenazine O-enantate
| 中文名称 | fluphenazine O-enantate |
|---|---|
| 中文同义词 | 氟奋乃静庚酸酯;氟奋乃静癸酸酯杂质C (EP);癸氟奋乃静杂质C(EP);氟奋乃静庚酸盐 EP标准品;癸氟奋乃静杂质3(癸氟奋乃静EP杂质C);2-[4-[3-[2-(三氟甲基)吩噻嗪-10-基]丙基]哌嗪-1-基]乙基庚酸酯;化合物 T11304;氟奋乃静酯 |
| 英文名称 | fluphenazine O-enantate |
| 英文同义词 | fluphenazine O-enantate;Heptanoic acid, 2-4-3-2-(trifluoromethyl)-10H-phenothiazin-10-ylpropyl-1-piperazinylethyl ester;moditen enanthate;2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl heptanoate;enanthic acid 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl ester;2-[4-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl heptanoate;Fluphenazine enantate CRS;Fluphenazine Decanoate Impurity 3 (Fluphenazine Decanoate EP Impurity C) |
| CAS号 | 2746-81-8 |
| 分子式 | C29H38F3N3O2S |
| 分子量 | 549.698 |
| EINECS号 | 2203850 |
| 相关类别 | Organics |
| Mol文件 | 2746-81-8.mol |
| 结构式 |  |
fluphenazine O-enantate 性质
| 熔点 | 184.5°C |
|---|---|
| 沸点 | 629.4±55.0 °C(Predicted) |
| 密度 | 1.1661 (estimate) |
| 溶解度 | 几乎不溶于水，极易溶于乙醇和二氯甲烷，易溶于甲醇。 |
| 酸度系数(pKa) | 7.32±0.10(Predicted) |
Fluphenazine enanthate 是第一种长效抗精神病药物，用于研究精神分裂症。
Fluphenazine enanthate (2,4, 8 mg/kg; IM) significant inhibition of the avoidance performance is observed as long as 16, 23, and 28 days, respectively.
Fluphenazine enanthate (8 mg/kg) drinking behavior is almost completely suppressed for 24 hours immediately following the administration.
Fluphenazine enanthate (8 mg/kg) produces transient body weight Iosses in the rats.
| Animal Model: | Fifty-four male adult rats of Wistar strain |
| Dosage: | 2, 4, and 8 mg/kg |
| Administration: | Index medicus (IM ) |
| Result: | Three doses of Fluphenazine enanthate significant inhibition of the avoidance performance was observed as long as 16, 23, and 28 days, respectively. |
安全信息
| 危险品运输编号 | 3249 |
|---|---|
| 危险等级 | 6.1(b) |
| 包装类别 | III |