贝托斯汀
| 中文名称 | 贝托斯汀 |
|---|---|
| 中文同义词 | 贝托斯汀;贝托司汀;4-[4-[(4-氯苯基)吡啶-2-基甲氧基]哌啶-1-基]丁酸;(+)-BEPOTASTINE;BEPOTASTINE >90%;苯钾碱;(S)-4-(4-((4-氯苯基)(吡啶-2-基)甲氧基)哌啶-1-基)丁酸;S)-贝托斯汀 |
| 英文名称 | BEPOTASTINE |
| 英文同义词 | 4-(4-[(1S)(4-CHLOROPHENYL)-2-PYRIDYLMETHOXY]PIPERIDYL)BUTANOIC ACID;1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-;betotastine besilate;4-[4-[(4-Chlorophenyl)pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid;(+)-(S)-4-[4-[1-(4-chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid;4-[(S)-(4-chlorophenyl)-2-pyridinylMethoxy]-;-4-(4-((4-Chlorophenyl);BEPOTASTINE |
| CAS号 | 125602-71-3 |
| 分子式 | C21H25ClN2O3 |
| 分子量 | 388.89 |
| EINECS号 | 200-258-5 |
| 相关类别 | 医药原料药;原料药;原料药及中间体 |
| Mol文件 | 125602-71-3.mol |
| 结构式 |  |
贝托斯汀 性质
| 熔点 | 56 - 58°C |
|---|---|
| 沸点 | 546.8±50.0 °C(Predicted) |
| 密度 | 1.26 |
| 储存条件 | -20°C Freezer, Under inert atmosphere |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 酸度系数(pKa) | 4.44±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至浅棕色 |
Histamine H1 receptor
Bepotastine possesses additional anti-allergic activity including stabilization of mast cell function, inhibition of eosinophilic infiltration, inhibition of IL-5 production, and inhibition of leukotriene B4 (LTB4) and LTD4 activity.
Bepotastine significantly inhibits antigen-induced stimulation of IL-5 production in human peripheral blood mononuclear cells (PBMCs) at concentrations of 10-100 μM and the effect is enhanced when the PBMCs are pre-incubated with Bepotastine.
Leukotriene B4 increased Ca2+ concentration in cultured neutrophils, which is suppressed by Bepotastine besilate (1-100 μM). Leukotriene B4 increased Ca2+ concentration in cultured dorsal root ganglion neurons, which is also suppressed by Bepotastine besilate (100 μM).
Bepotastine besilate (10 mg/kg) inhibits scratching induced by an intradermal injection of histamine (100 nmol/site), but not serotonin (100 nmol/site).
Bepotastine besilate (1-10 mg/kg, oral) dose-dependently suppresses scratching induced by substance P (100 nmol/site) and leukotriene B4 (0.03 nmol/site).
Bepotastine in vivo dose-dependently inhibits the acceleration of histamine-induced vascular permeability and inhibits homologous passive cutaneous anaphylaxis in guinea pig studies.
In mouse models of itching, oral Bepotastine inhibits the frequency and duration of scratching behavior.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-I0021 | Bepotastine | 5 mg | 750元 | |
| 2024/01/25 | HY-I0021 | 贝托斯汀 Bepotastine | 125602-71-3 | 10mg | 1200元 |