马来酸三甲丙咪嗪
中文名称 | 马来酸三甲丙咪嗪 |
---|---|
中文同义词 | 马来酸三甲丙咪嗪;曲米帕明马来酸盐;三甲丙咪嗪为峰鉴别 EP标准品;马来酸曲米帕明 USP标准品;马来酸三甲丙咪嗪 EP标准品;TRIMIPRAMINE MALEATE[干冰运输];马来酸三米普拉明;三甲丙咪嗪马来酸盐 |
英文名称 | TRIMIPRAMINE MALEATE SALT |
英文同义词 | TRIMIPRAMINE MALEATE SALT;f)azepine,10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-5h-dibenz(mal;surmontilmaleate;trimepriminemaleate;trimepriminemonomaleate;trimipramineacidmaleate;trimipramine hydrogen maleate;TRIMIPRAMINE MALEATE METHANOL SOLUTION |
CAS号 | 521-78-8 |
分子式 | C24H30N2O4 |
分子量 | 410.51 |
EINECS号 | 208-318-3 |
相关类别 | 小分子抑制剂;医药原料;标准品;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Biogenic Amine Transport Inhibitors;Biogenic Amine Transport InhibitorsObesity Research;Neurotransmission;Neurotransmission (Obesity);Neurotransmitters |
Mol文件 | 521-78-8.mol |
结构式 | ![]() |
马来酸三甲丙咪嗪 性质
熔点 | 141-143°C |
---|---|
闪点 | 11 °C |
储存条件 | 2-8°C |
溶解度 | 氯仿:可溶,50mg/ml,透明,无色至淡黄色 |
形态 | 粉末 |
颜色 | 白色 |
EPA化学物质信息 | Trimipramine maleate (521-78-8) |
5-HT 1C Receptor 6.39 (pKi) |
5-HT 2 Receptor 8.10 (pKi) |
sPLA2 4.66 (pKi) |
Trimipramine displays much higher affinity for 5-HT 2 than for 5-HT 1C receptors.
The chronic administration of Trimipramine (5 mg/kg/day), as delivered by the osmotic minipump in 14 days produce significant increases in the regional concentration of 5-HT. The increases are highest in the frontal cortex and the hippocampus, followed by the olfactory tubercles and the hypothalamus. The Trimipramine treatment also produces marked increases in brain 5-HIAA concentrations ranging from 63% in the hippocampus to 25% in the nucleus accumbens with intermediate values for the hypothalamus, olfactory tubercles, frontal cortex and nucleus accumbens. Trimipramine treatment produces significant increases in DA concentrations in the nucleus accumbens, striaturn, and olfactory tubercles reaching 43, 21 and 11% respectively. Chronic administration of Trimipramine produces a marked reduction in the number of frontal cortex 5-HT 2 and striatal DA D 2 receptors. The chronic administration of Trimipramine produces an increase in the brain regional level of monoamines and metabolites indicating a greater synthesis rate for DA and 5-HT coinciding with an adaptive down regulation of 5-HT 2 and DA D 2 receptors.
安全信息
危险品标志 | Xn,T,F |
---|---|
危险类别码 | 22-36/37/38-63-36/38-23/25-39/23/24/25-23/24/25-11 |
安全说明 | 26-36-45-33-24-16-7-36/37 |
危险品运输编号 | 3249 |
WGK Germany | 3 |
RTECS号 | HN9260000 |
危险等级 | 6.1(b) |
包装类别 | III |
海关编码 | 2933996100 |
提供商 | 语言 |
---|---|
英文
|