TRIMIPRAMINE MALEATE SALT

TRIMIPRAMINE MALEATE SALT Suppliers list
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: CAS:521-78-8
Purity:0.99 Package:25KG;5KG;1KG;500G
Company Name: Xi'an MC Biotech, Co., Ltd.
Tel: 029-89275612 +8618991951683
Email: mcbio_sales@163.com
Products Intro: Product Name:TRIMIPRAMINE MALEATE SALT
CAS:521-78-8
Purity:98% Package:1G;10G;1KG,5KG,10KG
Company Name: AFINE CHEMICALS LIMITED
Tel: 0571-85134551
Email: info@afinechem.com
Products Intro: Product Name:Trimipramine Maleate
CAS:521-78-8
Purity:98%+ Package:Standard or custom package Remarks:excellent quality and reliable supplier
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: 571-88938639 +8617705817739
Email: info@dycnchem.com
Products Intro: Product Name:trimipramine maleate
CAS:521-78-8
Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:High quality
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490
Email: info@gihichemicals.com
Products Intro: Product Name:trimipramine maleate
CAS:521-78-8
Purity:99 Package:5KG;1KG,25kg
TRIMIPRAMINE MALEATE SALT Basic information
Product Name:TRIMIPRAMINE MALEATE SALT
Synonyms:TRIMIPRAMINE MALEATE SALT;f)azepine,10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-5h-dibenz(mal;surmontilmaleate;trimepriminemaleate;trimepriminemonomaleate;trimipramineacidmaleate;trimipramine hydrogen maleate;TRIMIPRAMINE MALEATE METHANOL SOLUTION
CAS:521-78-8
MF:C24H30N2O4
MW:410.51
EINECS:208-318-3
Product Categories:Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Biogenic Amine Transport Inhibitors;Biogenic Amine Transport InhibitorsObesity Research;Neurotransmission;Neurotransmission (Obesity);Neurotransmitters
Mol File:521-78-8.mol
TRIMIPRAMINE MALEATE SALT Structure
TRIMIPRAMINE MALEATE SALT Chemical Properties
Melting point 141-143°C
Fp 11 °C
storage temp. 2-8°C
solubility chloroform: soluble50 mg/ml, clear, colorless to faintly yellow
form powder
color white
EPA Substance Registry SystemTrimipramine maleate (521-78-8)
Safety Information
Hazard Codes Xn,T,F
Risk Statements 22-36/37/38-63-36/38-23/25-39/23/24/25-23/24/25-11
Safety Statements 26-36-45-33-24-16-7-36/37
RIDADR 3249
WGK Germany 3
RTECS HN9260000
HazardClass 6.1(b)
PackingGroup III
HS Code 2933996100
MSDS Information
ProviderLanguage
SigmaAldrich English
TRIMIPRAMINE MALEATE SALT Usage And Synthesis
Chemical PropertiesWhite Crystalline Solid
OriginatorSurmontil Wyeth-Ayerst,Laboratories
UsesAntidepressant; serotonin transport blocker that also blocks norepinephrine uptake.
UsesAntidepressant;Noradrenaline uptake inhibitor
UsesAntidepressant; serotonin transport blocker that also blocks norepinephrine uptake
Manufacturing ProcessBis(3-dimethylamino-2-methylpropyl)-5-iminodibenzylyl carboxylic acid at 185-250°C up to discontinue a separation of oxyde carbonique. The product was dissolved in ether, then washed with the hydrochloric acid. Then this solution was extracted with ether. The solvent was evaporated under vacuum, to give pure oil bis(3-dimethylamino-2-methyl-1-propyl)-5-iminodibenzyle with boiling point 153-154°C at 0.4 mm. Maleate of bis(3-dimethylamino-2-methyl- 1-propyl)-5-iminodibenzyle have melting point 145-146°C.
Brand nameSurmontil (Odyssey).
Therapeutic FunctionAntidepressant
General DescriptionFor details of chemical nomenclature, consult the descriptionof imipramine. Replacement of hydrogen with an -methylsubstituent produces a chiral carbon, and trimipramine(Surmontil) is used as the racemic mixture. Biological propertiesreportedly resemble those of imipramine.
Biological Activitytrimipramine (maleate) is a potent antagonist of histamine h1 receptor, serotonin 5-ht2a, and α1-adrenergic receptors [1].the histamine h1 receptor is widely expressed tissues, such as smooth muscles, vascular endothelial cells, heart, and the central nervous system. histamine h1 receptor (h1r) antagonists are very effective drugs alleviating the symptoms of allergic reactions [2]. 5-ht2a receptor shows constitutive activity. variations in5-ht2a receptor can produce profound alterations in cognitive states [3]. the adrenergic receptors play an important role in modulating sympathetic nervous system activity as well as a site of action for many therapeutic agents. the α1-adrenergic receptor is the prime mediators of smooth muscle contraction and hypertrophic growth. the α1-adrenergic receptor plays an essential role in smooth muscle, growth, neurological, and cardiovascular function [4].trimipramine (maleate) is a tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors. trimipramine potently antagonized the activity of histamine h1 serotonin 5-ht2a, and α1-adrenergic receptors with the kd value of 0.27 nm, 24 nm, and 24 nm, respectively. trimipramine moderately antagonized the activity of dopamine d2 with the kd of 180 nm. trimipramine inhibited the activity of muscarinic acetylcholine with the kd of 58 nm. trimipramine weakly inhibited the activity of 5-ht2c, d1, α2-adrenergic receptors (kd = 680 nm) [1]. trimipramine (maleate) was a weak to moderate reuptake inhibitor of serotonin (ki = 149 nm for sert), and an extremely weak inhibitor of norepinephrine (ki = 2.5 μm for net) and dopamine (ki = 3.8 μm for dat) reuptake in slices of rat cerebral cortex [5,6].
Biochem/physiol ActionsAntidepressant; serotonin transport blocker that also blocks norepinephrine uptake.
references[1] richelson e, nelson a. antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro[j]. journal of pharmacology and experimental therapeutics, 1984, 230(1): 94-102.
[2] shimamura t, shiroishi m, weyand s, et al. structure of the human histamine h1 receptor complex with doxepin[j]. nature, 2011, 475(7354): 65-70.
[3] harvey j a. role of the serotonin 5-ht2a receptor in learning[j]. learning & memory, 2003, 10(5): 355-362.
[4] piascik m t, perez d m. α1-adrenergic receptors: new insights and directions[j]. journal of pharmacology and experimental therapeutics, 2001, 298(2): 403-410.
[5] gross g, xie x, gastpar m. trimipramine: pharmacological reevaluation and comparison with clozapine[j]. neuropharmacology, 1991, 30(11): 1159-1166.
[6] tatsumi m, groshan k, blakely r d, et al. pharmacological profile of antidepressants and related compounds at human monoamine transporters[j]. european journal of pharmacology, 1997, 340(2): 249-258.
TRIMIPRAMINE MALEATE SALT Preparation Products And Raw materials
Tag:TRIMIPRAMINE MALEATE SALT(521-78-8) Related Product Information
Triprolidine oxalate salt Trimipramine-D3 maleate Trimebutine maleate Chlorphenamine maleate TRIMIPRAMINE Enalapril maleate Iminodibenzyl IMIPRAMINE DESIPRAMINE Trimipramine-d3 Maleate Salt TRIMIPRAMINE MALEATE SALT