1,4-二氢-6-(1H-咪唑-1-基)-7-硝基-2,3-喹喔啉二酮单盐酸盐
| 中文名称 | 1,4-二氢-6-(1H-咪唑-1-基)-7-硝基-2,3-喹喔啉二酮单盐酸盐 |
|---|---|
| 中文同义词 | 1,4-二氢-6-(1H-咪唑-1-基)-7-硝基-2,3-喹喔啉二酮单盐酸盐;1,4-二氢-6-(1H-咪唑-1-基)-7-硝基-2,3-喹啉二酮单盐酸盐;化合物YM90K HYDROCHLORIDE;6-(1H-咪唑-1-基)-7-硝基-2,3(1H,4H)-喹喔啉二酮;YM 90K盐酸盐 |
| 英文名称 | YM90Khydrochloride |
| 英文同义词 | YM 90K;1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione monohydrochloride;YM90Khydrochloride;6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione;1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedionehydrochloride;2,3-Quinoxalinedione,1,4-dihydro-6-(1H-imidazol-1-yl)-7-nitro-,monohydrochloride;YM-90K HCL;CS-885 |
| CAS号 | 154164-30-4 |
| 分子式 | C11H7N5O4.HCl |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 154164-30-4.mol |
| 结构式 |  |
1,4-二氢-6-(1H-咪唑-1-基)-7-硝基-2,3-喹喔啉二酮单盐酸盐 性质
| 储存条件 | Desiccate at RT |
|---|---|
| 溶解度 | 温和加热时在 DMSO 中溶解至 10 mM |
| 形态 | 粉末 |
Ki: 84 nM (AMPA receptor), 2.2 μM (Kainate receptor) and 37 μM (NMDA receptor)
YM90K co-injected with AMPA or kainate into the rat striatum protect cholinergic neurons against AMPA- or kainate-induced neurotoxicity.
YM90K shows potent suppressive activity against audiogenic seizure in DBA/2 mice; ED
50
values of YM90K against tonic seizure is 2.54 mg/kg (i.p.). The duration of the anticonvulsant effects of YM90K is 30 min.
In a global ischemia model, YM90K (15 mg/kg i.p.) significantly prevents the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia. The therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p.) is 6 h.
In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduces the volume of ischemic damage in the cerebral cortex in F344 rats.