小豆蔻明
中文名称 | 小豆蔻明 |
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中文同义词 | 小豆蔻明;(E)-1-(2,4-二羟基-6-甲氧基苯基)-3-苯基丙-2-烯-1-酮;小豆蔻明、豆蔻素、小豆蔻查耳酮;豆寇明(小豆蔻明,豆蔻素,小豆蔻查耳酮);豆蔻素、小豆蔻查耳酮;豆寇明;CARDAMONIN 小豆蔻明;豆寇明(小豆蔻明 |
英文名称 | CARDAMONIN |
英文同义词 | Alpinetin chalcone;Chalcone, 2', 4'-dihydroxy-6'-methoxy-;(E)-2',4'-Dihydroxy-6'-methoxychalcone;(E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one;Cardamonin;(E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one;2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-, (2E)-;CARDAMONIN(RG) |
CAS号 | 19309-14-9 |
分子式 | C16H14O4 |
分子量 | 270.28 |
EINECS号 | |
相关类别 | 小分子抑制剂,天然产物;植物提取物;对照品;小分子抑制剂;中药对照品;标准品;对照品-中药对照品;查尔酮;Chalcones;Inhibitors;标准品 -中药标准品;分析试剂-对照品;标准品,对照品 |
Mol文件 | 19309-14-9.mol |
结构式 |
小豆蔻明 性质
熔点 | 199~200℃ |
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沸点 | 484.5±45.0 °C(Predicted) |
密度 | 1.282±0.06 g/cm3(Predicted) |
储存条件 | room temp |
溶解度 | 二甲基亚砜:≥20mg/mL |
酸度系数(pKa) | 7.00±0.40(Predicted) |
形态 | 粉末 |
颜色 | 粘黄色 |
稳定性 | DMSO或乙醇溶液可在-20°下稳定储存2周。 |
Target | Value |
NF-κB
(Cell-free assay) | |
TRPA1
(Cell-free assay) | 454 nM |
(E)-Cardamonin ((E)-Cardamomin) selectively blocksTRPA1 activation (IC 50 =454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. (E)-Cardamonin ((E)-Cardamomin) does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. (E)-Cardamonin ((E)-Cardamomin) suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
(E)-Cardamonin ((E)-Cardamomin) (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/01/25 | HY-N1378 | 小豆蔻明 (E)-Cardamonin | 19309-14-9 | 5mg | 250元 |
2024/01/25 | HY-N1378 | 小豆蔻明 (E)-Cardamonin | 19309-14-9 | 10mg | 400元 |