Tritoqualine
| 中文名称 | Tritoqualine |
|---|---|
| 中文同义词 | 酞茂异喹;化合物 T17166 |
| 英文名称 | Tritoqualine |
| 英文同义词 | 7-Amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one;Hypostamine;Inhibostamin;Tritocalin;1(3H)-Isobenzofuranone, 7-amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)- |
| CAS号 | 14504-73-5 |
| 分子式 | C26H32N2O8 |
| 分子量 | 500.54 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 14504-73-5.mol |
| 结构式 |  |
Tritoqualine 性质
| 熔点 | 183° |
|---|---|
| 沸点 | 647.2±55.0 °C(Predicted) |
| 密度 | 1.296±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 6.22±0.40(Predicted) |
histidine decarboxylase
The effect of Tritoqualine (TRQ) on the CCl 4 -induced enzyme leakage is investigated by pretreatment of rats with Tritoqualine (200 mg/kg/day, p.o., 7 days). The ratio of lactate dehydrogenase (LDH) release from the cells of Tritoqualine-pretreated rats is significantly less than that in control rats. The rate of malondialdehyde (MDA) production is accelerated after the addition of 7.8 mM CCl 4 . Tritoqualine reduces its rate in a dose dependent manner, and it completely prevents CCl 4 -stimulated lipid peroxidation at a concentration of 33 μM.
A single administration of CCl 4 (0.75 mL/kg, p.o.) causes a five-fold increase of in vivo lipid peroxidation in the liver. In contrast, a reduction of 37% in the lipid peroxidation is obtained by Tritoqualine (100 mg/kg) pretreatment for 14 days prior to CCl 4 treatment. A 63% reduction is observed in vitamin E (25 mg/kg) pretreated rats.