4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺
| 中文名称 | 4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺 |
|---|---|
| 中文同义词 | 2,2-双(4-氟苯基)-2-苯乙酰胺;4-氟-ALPHA-(4-氟苯基)-ALPHA-苯基苯乙酰胺;塞尼卡泊;2,2-双(4-氟苯)-2-苯乙酰胺;4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺;SENICAPOC,通道阻断剂 |
| 英文名称 | 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide |
| 英文同义词 | 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-;4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;ICA 17043;Senicapoc;ICA-17043;ICA 17043;ICA17043;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl- |
| CAS号 | 289656-45-7 |
| 分子式 | C20H15F2NO |
| 分子量 | 323.34 |
| EINECS号 | |
| 相关类别 | 离子通道;膜转运 |
| Mol文件 | 289656-45-7.mol |
| 结构式 |  |
4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺 性质
| 熔点 | 180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2)) |
|---|---|
| 沸点 | 460.7±45.0 °C(Predicted) |
| 密度 | 1.250±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMSO：50 mg/mL（154.64 mM；需要超声波） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 15.41±0.50(Predicted) |
IC50: 11 nM (Gardos channel)
ICA-17043 is shown to block the Gardos channel of mouse (C57 Black) RBCs with an IC 50 of 50±6 nM. ICA-17043 blocks this increase in cellular hemoglobin concentration in human RBCs in a concentration-dependent fashion.
ICA-17043 (10 mg/kg, p.o.) administration produces a significant decrease in Gardos channel activity measured at day 11 and 21 and is associated with a corresponding increase in red cell K + content without changes in Na + content. ICA-17043 (10 mg/kg, twice a day) induces a significant increase in Hct after 11 days of dosing in the SAD mouse. Senicapoc (30 mg/kg, p.o.) reduces airway hyperresponsiveness, eosinophil numbers in bronchoalveolar lavage taken 48 hours post-allergen challenge, and vascular remodelling in the sheep.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-50694 | Senicapoc | 5 mg | 604元 | |
| 2024/01/25 | HY-50694 | 4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺 Senicapoc | 289656-45-7 | 10mg | 967元 |