辅酶Q9
| 中文名称 | 辅酶Q9 |
|---|---|
| 中文同义词 | 泛醌-45;泛醌-9;辅酶Q9;辅酶Q9(标准品);辅酶Q10杂质;癸利酮杂质1(辅酶Q9);辅酶杂质D;辅酶 Q9, 用于生化 |
| 英文名称 | COENZYME Q9 |
| 英文同义词 | ,6,10,14,18,22,26,30,34-hexatriacontanonaenyl)-;coenzymeq(sub9);coq(sub9);p-benzoquinone,2,3-dimethoxy-5-methyl-6-(3,7,11,15,19,23,27,31,35-nonamethyl-2;ubiquinoneq(sub9);Q-9;coenzyme Q9 from candida utilis;COENZYME Q9 |
| CAS号 | 303-97-9 |
| 分子式 | C54H82O4 |
| 分子量 | 795.23 |
| EINECS号 | 215-668-0 |
| 相关类别 | 合成;Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols |
| Mol文件 | 303-97-9.mol |
| 结构式 |  |
辅酶Q9 性质
| 熔点 | 41-43°C |
|---|---|
| 沸点 | 826.8±65.0 °C(Predicted) |
| 密度 | 0.97±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 可溶于氯仿（轻微）、乙酸乙酯（轻微）、甲醇（轻微、加热） |
| 颜色 | 黄色至橙色粘性至蜡状 |
| BRN | 1900081 |
| 稳定性 | 感光 |
|
Human Endogenous Metabolite
|
Coenzyme Q9 (5 mg/kg; p.o.; once a day for 4 weeks) reduces myocardial ischemia/reperfusion injury.
CoQ
10
and CoQ
9
are components of themitochondrial respiratory chain in mammals and can regulate some mitochondrial proteins/functions. Soybean, corn, and rapeseed oils are very rich sources of CoQ
10
, whereas CoQ
9
has been found in high concentrations in corn oil.
The lack of a functional CoQ
9
protein in homozygous CoQ
9
mutant (CoQ
9
(X/X)) mice causes a severe reduction in the CoQ
7
protein and a widespread CoQ deficiency and accumulation of demethoxyubiquinone. The deficit in CoQ induces a brain-specific impairment of mitochondrial bioenergetics performance, a reduction in respiratory control ratio, ATP levels and ATP/ADP ratio and specific loss of respiratory complex I. These effects lead to neuronal death and demyelinization with severe vacuolization and astrogliosis in the brain of CoQ
9
(X/X) mice that consequently die between 3 and 6 months of age.
| Animal Model: | Male Hartley guinea pigs of about 350-400 g body weight |
| Dosage: | 5 mg/kg of body weight |
| Administration: | P.o.; once a day for 4 weeks |
| Result: | Nutritional supplementation of CoQ9 can reduce myocardial ischemia/reperfusion injury to the same extent as CoQ10. |
| 提供商 | 语言 |
|---|---|
|
英文
|