VEGFR2 KISE INHIBITOR I
| 中文名称 | VEGFR2 KISE INHIBITOR I |
|---|---|
| 中文同义词 | RAMUCIRUMAB ( 雷莫芦单抗 );2,4-二甲基-5-((2-氧吲哚-3-亚甲基)甲基)-1H-吡咯-3-羧酸乙酯;化合物VEGFR2 KINASE INHIBITOR I;VEGFR2激酶抑制剂I |
| 英文名称 | VEGFR2 Kinase Inhibitor I |
| 英文同义词 | SU5408;VEGFR2 KISE INHIBITOR I;VEGFR2 Kinase Inhibitor I;VEGFR2 TK Inhibitor;SU 5408;SU-5408;SU5408;VEGFR2 kinase inhibitor I(SU-5408);1H-Pyrrole-3-carboxylic acid, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-, ethyl ester;Research Grade Ramucirumab(DHE16601) |
| CAS号 | 15966-93-5 |
| 分子式 | C18H18N2O3 |
| 分子量 | 310.35 |
| EINECS号 | |
| 相关类别 | Growth Factors and Cytokines;Angiogenesis and Metastasis |
| Mol文件 | 15966-93-5.mol |
| 结构式 |  |
VEGFR2 KISE INHIBITOR I 性质
| 沸点 | 571.4±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.271±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMF：1mg/mL；二甲基亚砜：1mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 12.40±0.20(Predicted) |
SU5408 (VEGFR2 Kinase Inhibitor I)是一种有效、选择性 VEGFR2 Kinase抑制剂，IC50为70 nM。
| Target | Value |
|
VEGFR2
(Cell-free assay) | 70 nM |
3-Substituted indolin-2-ones have been designed and synthesized as a novel class of tyrosine kinase inhibitors which exhibit selectivity toward different receptor tyrosine kinases (RTKs). These compounds have been evaluated for their relative inhibitory properties against a panel of RTKs in intact cells. SU5408 (VEGFR2 Kinase Inhibitor I) is found to be the most potent and selective VEGFR2 inhibitor among the compounds. SU5408 (VEGFR2 Kinase Inhibitor I) shows little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC 50 >100 µM).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-103002 | VEGFR2 KISE INHIBITOR I SU5408 | 15966-93-5 | 1 mg | 900元 |
| 2024/01/25 | HY-103002 | VEGFR2 KISE INHIBITOR I SU5408 | 15966-93-5 | 5mg | 3900元 |