LY 254155
| 中文名称 | LY 254155 |
|---|---|
| 中文同义词 | 化合物 T11922 |
| 英文名称 | LY 254155 |
| 英文同义词 | LY 254155;GQCXGHHHNACOGE-ACGXKRRESA-N;L-Glutamic acid, N-[[5-[2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl)ethyl]-2-thienyl]carbonyl]- (9CI) |
| CAS号 | 135503-67-2 |
| 分子式 | C19H23N5O6S |
| 分子量 | 449.48 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 135503-67-2.mol |
| 结构式 |  |
LY 254155 性质
| 密度 | 1.68±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 3.50±0.10(Predicted) |
LY 254155 是一种抗叶酸剂。LY 254155 抑制 hGARFT 及与 mFBP 结合，Kis 分别为 2.1±0.2 和 1.7±0.1 nM。
Ki: 2.1±0.2 (hGARFT ), 1.7± 0.1 nM (mFBP)
LY 254155 inhibits recombinant human monofunctional glycinamide ribonucleotide formyltransferase (hGARFT) and binds to membrane folate-binding protein (mFBP) .
LY 254155 is active against a broad panel of murine and human xenograft solid tumors. LY 254155 (5, 10, 20, and 40 mg/kg) inhibits murine C3H carcinoma growth in C3H mice, with % inhibition of tumor growth is 49%, 71%, 90%, and 94%, respectively.