N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate
生物活性体内研究 用途与合成方法 MSDS N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate价格(试剂级) 上下游产品信息
中文名称 | N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate |
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中文同义词 | 化合物BIBO3304 TFA;(R)-2-(2,2-二苯基乙酰胺基)-5-胍基-N-(4-(脲基甲基)苄基)戊酰胺 2,2,2-三氟乙酸盐 |
英文名称 | N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate |
英文同义词 | BIBO 3304 trifluoroacetate;N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate;BIBO 3304;BIBO 3304 (BIBO3304);BIBO3304 TFA;BIBO 3304 trifluoroa;(R)-2-(2,2-Diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide 2,2,2-trifluoroacetate;N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate |
CAS号 | 191868-14-1 |
分子式 | C31H36F3N7O5 |
分子量 | 643.67 |
EINECS号 | |
相关类别 | |
Mol文件 | 191868-14-1.mol |
结构式 |
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate 性质
储存条件 | Store at +4°C |
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溶解度 | <75.77mg/ml,溶于 DMSO; <75.77mg/ml,乙醇中 |
形态 | 固体 |
颜色 | 白色 |
N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate 用途与合成方法
BIBO3304 TFA 是一种高效的、具有口服活性的、选择性的神经肽Y (NPY) Y1 受体拮抗剂,对人和大鼠 Y1 受体均具有高亲和力 (IC50 分别为 0.38 和 0.72 nM)。
BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting.
BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY.
BIBO3304 TFA (0.5 μM; p.o.) significantly increases serum insulin levels.
Animal Model: | Adult male Chbb:Thom rats weighing between 300 and 340 g |
Dosage: | 30 μg |
Administration: | bilateral paraventricular nucleus injection |
Result: | Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding. |
Animal Model: | 7-week-old C57BL/6JAusb mice |
Dosage: | 0.5 μM |
Administration: | p.o. |
Result: | Significantly increased serum insulin levels. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-107725 | BIBO3304 TFA | 1 mg | 1047元 | |
2024/04/30 | HY-107725 | N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate BIBO3304 TFA | 191868-14-1 | 5mg | 2488元 |