KONGENSIN A

KONGENSIN A

中文名称KONGENSIN A
中文同义词化合物 T5136
英文名称Kongensin A
英文同义词Kongensin A;7,10-Methano-7H-benzocycloundecene-8,13-dione, 1-(acetyloxy)-1,2,3,4,4a,5,6,9,10,11,12,13a-dodecahydro-6-hydroxy-4,4,13a-trimethyl-9-methylene-, (1R,4aR,6R,10R,13aS)-
CAS号885315-96-8
分子式C22H30O5
分子量374.4706
EINECS号
相关类别植物提取物;二萜
Mol文件885315-96-8.mol
结构式KONGENSIN A 结构式

KONGENSIN A 性质

熔点160-162 °C(Solv: chloroform (67-66-3))
沸点525.7±50.0 °C(Predicted)
密度1.17±0.1 g/cm3(Predicted)
储存条件4°C, protect from light
酸度系数(pKa)13.07±0.70(Predicted)

KONGENSIN A 用途与合成方法

Kongensin A 是一种从 Croton kongensis 中分离的天然产物。 Kongensin A 是一种有效的,共价的 HSP90 抑制剂,可阻断 RIP3 依赖性坏死病。Kongensin A 是一种有效的坏死性抑制剂和凋亡诱导剂,并具有潜在的抗坏死性和消炎性应用。

HSP90
RIP3
Apoptosis

Kongensin A (0-15 μM; 6 hours; HT29 cells) treatment induces caspase activation and apoptosis in multiple cancer cell lines in a dosage-dependent manner.
Kongensin A (0-15 μM; 24 hours; HT29 cells) treatment induces the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induces the up-regulation of HSP90A and HSP90B.
Kongensin A covalently binds to cysteine 420 in the middle domain of HSP90 and dissociates HSP90 from its cochaperone CDC37. The HSP90-CDC37 complex is required for RIP3 activation, KA blocks LPS/Smac mimetics/Z-VAD and RIP3 polymerization-induced cell death, in which cell death is dependent on RIP3 but not its upstream kinase RIP1.

Apoptosis Analysis

Cell Line: HT29 cells
Concentration: 0 μM, 2.5 μM, 5 μM, 15 μM
Incubation Time: 6 hours
Result: Induced caspase activation and apoptosis in a dosage-dependent manner.

Western Blot Analysis

Cell Line: HT29 cells
Concentration: 0 μM, 2.5 μM, 5 μM, 15 μM
Incubation Time: 24 hours
Result: Induced the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induced the up-regulation of HSP90A and HSP90B.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-N3417KONGENSIN A
Kongensin A
885315-96-81 mg9500元
2023/03/20HY-N3417KONGENSIN A
Kongensin A
885315-96-85 mg20800元

KONGENSIN A 上下游产品信息

"KONGENSIN A"相关产品信息
荭草素-2"-O-BETA-L-半乳糖苷 beta-桉叶醇 5-羟基-6,7-二甲氧基黄酮 蜕皮激素 α-松油醇 羟基芫花素 蒿甲醚 桤木酮 alpha-香附酮 β-谷甾醇
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