4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯
| 中文名称 | 4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯 |
|---|---|
| 中文同义词 | 4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯;化合物JZL195 |
| 英文名称 | JZL 195 |
| 英文同义词 | JZL 195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;CS-1586;JZL-195;JZL 195;JZL195;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195 |
| CAS号 | 1210004-12-8 |
| 分子式 | C24H23N3O5 |
| 分子量 | 433.46 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;医药;Inhibitors;API |
| Mol文件 | 1210004-12-8.mol |
| 结构式 |  |
4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯 性质
| 沸点 | 581.8±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.303±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 加热时在DMSO中的溶解度≥5mg/mL |
| 酸度系数(pKa) | 6.13±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
JZL195是有效的FAAH和MAGL抑制剂，IC50分别为2 nM和4 nM。
| Target | Value |
|
FAAH
() | 2 nM |
|
MAGL
() | 4 nM |
JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC
50
values of 13 and 19 nM, respectively).
JZL195 inhibits rat and human FAAH and MAGL enzymes with IC
50
values in the range of ≈10-100 nM based on competitive ABPP assays.
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay.
| Animal Model: | Male C57BL/6J mice |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-15250 | 4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯 JZL195 | 1210004-12-8 | 5mg | 500元 |
| 2024/01/25 | HY-15250 | JZL195 | 10 mM * 1 mLin DMSO | 550元 |