T16AINH-A01
| 中文名称 | T16AINH-A01 |
|---|---|
| 中文同义词 | 2-[(5-乙基-1,6-二氢-4-甲基-6-氧代-2-嘧啶基)硫代] -N-[4-(4-甲氧基苯基)-2-噻唑基]乙酰胺;化合物T16AINH-A01;T16AINH-A01;INHIBITOR OF TMEM16A;2-((5-乙基-4-甲基-6-氧代-1,6-二氢嘧啶-2-基)硫代)-N-(4-(4-甲氧基苯基)噻唑-2-基)乙酰胺 |
| 英文名称 | TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) |
| 英文同义词 | TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01);T16Ainh-A01;2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide;TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem;Acetamide, 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-;inhibitor of TMEM16A;2-((5-Ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide;inhibit,T16AinhA01,Chloride Channel,T16Ainh-A01,T-16Ainh-A01,T16Ainh A01,Cl-Channels,Inhibitor |
| CAS号 | 552309-42-9 |
| 分子式 | C19H20N4O3S2 |
| 分子量 | 416.52 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 552309-42-9.mol |
| 结构式 |  |
T16AINH-A01 性质
| 熔点 | 211-212°C (dec.) |
|---|---|
| 密度 | 1.39±0.1 g/cm3(Predicted) |
| 储存条件 | room temp |
| 溶解度 | DMSO：可溶5mg/mL，澄清（加热） |
| 酸度系数(pKa) | 7.20±0.50(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
T16Ainh-A01 是一种有效的、选择性的 calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) 的抑制剂，IC50为1.8 μM。
| Target | Value |
|
TMEM16A
(Cell-free assay) | 1.8 μM |
T16Ainh-A01 (0.3-30 μM) significantly reduces both inward and outward components of I
ClCa
, and inhibits I
ClCa
in RUICC without significantly affecting L-type Ca
2+
current.
T16Ainh-A01 (10 μM) inhibits nearly completely TMEM16A chloride current (induced by 275 nM free calcium in the pipette) at all voltages, indicating a voltage-independent block mechanism.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100612 | T16AINH-A01 T16Ainh-A01 | 552309-42-9 | 5mg | 850元 |
| 2024/01/25 | HY-100612 | T16AINH-A01 T16Ainh-A01 | 552309-42-9 | 10mM * 1mLin DMSO | 990元 |