YE-120 基本信息
| 中文名称 | YE-120 |
|---|---|
| 中文同义词 | 化合物 T23542;化合物 YE 120;2-(3-氰基-5-(3,4-二氯苯基)-4,5-二甲基呋喃-2(5H)-亚基)丙二腈 |
| 英文名称 | YE-120 |
| 英文同义词 | YE-120;2-[3-Cyano-5-(3,4-dichloro-phenyl)-4,5-dimethyl-5H-furan-2-ylidene]-malononitrile;2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile;Propanedinitrile, 2-[3-cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]-;2-(3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethylfuran-2(5H)-ylidene)malononitrile |
| CAS号 | 383124-82-1 |
| 分子式 | C16H9Cl2N3O |
| 分子量 | 330.17 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 383124-82-1.mol |
| 结构式 |  |
YE-120 性质
| 沸点 | 419.1±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 在 DMSO 中溶解度为 100 mM |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
用途
YE-120 is a GPR35 agonist (EC50 = 32 nM in DMR assays). YE-120 also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM). GPR35 is a Class A, rhodopsin-like G protei n-coupled receptor which is predominantly expressed in immune and gastrointestinal tissue, with notable expression in the ileum (rat and human GPR35), the spleen (rat and murine GPR35) and the pancrea s (human GPR35).