YE-120 基本信息
中文名称 | YE-120 |
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中文同义词 | 化合物 T23542 |
英文名称 | YE-120 |
英文同义词 | YE-120;2-[3-Cyano-5-(3,4-dichloro-phenyl)-4,5-dimethyl-5H-furan-2-ylidene]-malononitrile;2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile;Propanedinitrile, 2-[3-cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]- |
CAS号 | 383124-82-1 |
分子式 | C16H9Cl2N3O |
分子量 | 330.17 |
EINECS号 | |
相关类别 | |
Mol文件 | 383124-82-1.mol |
结构式 |
YE-120 性质
沸点 | 419.1±45.0 °C(Predicted) |
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密度 | 1.42±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 在 DMSO 中溶解度为 100 mM |
形态 | 粉末 |
颜色 | 白色至米白色 |
用途
YE-120 is a GPR35 agonist (EC50 = 32 nM in DMR assays). YE-120 also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM). GPR35 is a Class A, rhodopsin-like G protei n-coupled receptor which is predominantly expressed in immune and gastrointestinal tissue, with notable expression in the ileum (rat and human GPR35), the spleen (rat and murine GPR35) and the pancrea s (human GPR35).