DEBIO 0932 基本信息
| 中文名称 | DEBIO 0932 |
|---|---|
| 中文同义词 | HSP90抑制剂(DEBIO 0932);德比奥 0932;化合物 T15088;BIO 0932 |
| 英文名称 | Debio 0932 ,CUDC-305 |
| 英文同义词 | Debio 0932;Debio 0932 ,CUDC-305;CUDC-305 (DEBIO-0932 );CUDC-305;1H-Imidazo[4,5-c]pyridine-1-ethanamine, 4-amino-2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]thio]-N-(2,2-dimethylpropyl)-;CS-1423;bio 0932 |
| CAS号 | 1061318-81-7 |
| 分子式 | C22H30N6O2S |
| 分子量 | 442.58 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1061318-81-7.mol |
| 结构式 |  |
DEBIO 0932 性质
| 沸点 | 654.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.32±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO:33.0(最大浓度 mg/mL);74.56(最大浓度 mM) |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 10.02±0.19(Predicted) |
用途
一种HSP90(热休克蛋白90)抑制剂，对 HSP90α和 HSP90β的IC50值分别为100和103nM。Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance.安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-13469 | DEBIO 0932 Debio 0932 | 1061318-81-7 | 2mg | 950元 |
| 2024/01/25 | HY-13469 | DEBIO 0932 Debio 0932 | 1061318-81-7 | 10mM * 1mLin DMSO | 1363元 |