MONOMETHYLAURISTATIN F HYDROCHLORIDE
| 中文名称 | MONOMETHYLAURISTATIN F HYDROCHLORIDE |
|---|---|
| 中文同义词 | 细胞分裂抑制剂(MMAF HYDROCHLORIDE);化合物 T16121 |
| 英文名称 | MMAF (Hydrochloride) |
| 英文同义词 | MMAF (Hydrochloride);Monomethylauristatin F Hydrochloride;MMAF HCl;CS-1270;((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine hydrochloride |
| CAS号 | 1415246-68-2 |
| 分子式 | C39H66ClN5O8 |
| 分子量 | 768.43 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1415246-68-2.mol |
| 结构式 |  |
MONOMETHYLAURISTATIN F HYDROCHLORIDE 性质
| 储存条件 | Store at -20°C,unstable in solution, ready to use. |
|---|---|
| 溶解度 | DMSO：27 mg/mL（35.14 mM 和升温） |
MMAF (Monomethylauristatin F) hydrochloride 是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂，用作抗肿瘤药物。MMAF hydrochloride 广泛用作抗体偶联药物 (ADCs) 的细胞毒性成分，如 Vorsetuzumab mafodotin 和 SGN-CD19A。
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Auristatin
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MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC 50 s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay.
The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF 4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF 4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-15579A | MONOMETHYLAURISTATIN F HYDROCHLORIDE MMAF hydrochloride | 1415246-68-2 | 10mg | 560元 |
| 2024/04/30 | HY-15579A | MONOMETHYLAURISTATIN F HYDROCHLORIDE MMAF hydrochloride | 1415246-68-2 | 50 mg | 1280元 |