| Company Name: |
Cato Research Chemicals Inc.
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| Tel: |
020-81960175 |
| Email: |
min.he@cato-chem.com |
| Products Intro: |
Product Name:EveroliMus-d4 (~90%)
Purity:95% Package:25Mg, 50Mg
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| Company Name: |
Artis Biotech Co. Ltd.
|
| Tel: |
0575-0575-89298960 18582380095 |
| Email: |
sales@artisbio.com |
| Products Intro: |
Product Name:Everolimus-d4
CAS:1338452-54-2
Purity:98% HPLC Package:1mg 、5mg、10mg、50mg、 100mg、1g
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| Company Name: |
Nanjing Haolv Biotechnology Co.,Ltd
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| Tel: |
025-84622273 02584622273; |
| Email: |
kexin.zhou@haolvbiotech.com |
| Products Intro: |
Product Name:Everolimus-d4
CAS:1338452-54-2
Purity:98%+ Package:5g;1g;500mg;100mg;25mg;10mg
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|
| | EveroliMus-d4 Basic information |
| Product Name: | EveroliMus-d4 | | Synonyms: | EveroliMus-d4 (~90%);Everolimus-d4;Everolimus D4Q: What is
Everolimus D4 Q: What is the CAS Number of
Everolimus D4 Q: What is the storage condition of
Everolimus D4 Q: What are the applications of
Everolimus D4;EVEROLIMUS (2-HYDROXYETHYL-D4, 98%);Everolimus Impurity 24(Everolimus-d4);Everolimus-d4 (Everolimus Impurity) | | CAS: | 1338452-54-2 | | MF: | C53H79D4NO14 | | MW: | 962.249067112 | | EINECS: | | | Product Categories: | | | Mol File: | 1338452-54-2.mol |  |
| | EveroliMus-d4 Chemical Properties |
| storage temp. | Store at 4°C | | solubility | Chloroform: Soluble,Methanol: Soluble | | form | A solid | | Stability: | Hygroscopic |
| | EveroliMus-d4 Usage And Synthesis |
| Description | Everolimus-d4 is intended for use as an internal standard for the quantification of everolimus by GC- or LC-MS. Everolimus is a hydroxyethyl ether form of rapamycin that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM. It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin. Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer. It also acts as an immunosuppressive agent in the context of organ transplantation. | | Uses | Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation. | | General Description | A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress? and Certican for use in organ transplantation and Afinitor? for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis. |
| | EveroliMus-d4 Preparation Products And Raw materials |
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Tag:EveroliMus-d4(1338452-54-2)
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