4-O-甲基刺甘草查尔酮
| 中文名称 | 4-O-甲基刺甘草查尔酮 |
|---|---|
| 中文同义词 | 4-O-甲基刺甘草查尔酮;(E)-3-(2,4-二甲氧基苯基)-1-(4-羟基苯基)丙-2-烯-1-酮 |
| 英文名称 | 4'-Hydroxy-2,4-dimethoxychalcone |
| 英文同义词 | 4'-Hydroxy-2,4-dimethoxychalcone;2-Propen-1-one, 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-;4-O-Methylechinatin;(E)-3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one;(2E)-3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one;4'-Hydroxy-2,4-dimethoxychalcone |
| CAS号 | 151135-64-7 |
| 分子式 | C17H16O4 |
| 分子量 | 284.31 |
| EINECS号 | |
| 相关类别 | 中药对照品;查尔酮 |
| Mol文件 | 151135-64-7.mol |
| 结构式 |  |
4-O-甲基刺甘草查尔酮 性质
4'-Hydroxy-2,4-dimethoxychalcone 是龙血天竺葵红色草药树脂中的天然查尔酮衍生物。4'-Hydroxy-2,4-dimethoxychalcone 具有广泛的生物学活性，包括抗疟疾，抗原生动物，抗细菌，抗真菌活性。
4'-Hydroxy-2,4-dimethoxychalcone (compound 2) is against P. falciparum D6 (IC 50 =4.2 μM) and W2 (IC 50 =4.8 μM).
4'-Hydroxy-2,4-dimethoxychalcone (compound 2; oral; 160 mg/kg) has a T 1/2 of 1.94 hours, a C max of 158 ng/mL and an AUC of 384 ng•h/mL in four- to five-week-old ICR mice.