LJI308
中文名称 | LJI308 |
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中文同义词 | RSK抑制剂(LJI308);2,6-二氟-4-(4-吗啉苯基)吡啶-3-基)苯酚;化合物LJI308;LJI308,RSK抑制剂 |
英文名称 | LJI308 |
英文同义词 | LJI308;LJI 308;LJI308;LJI-308;LJI 308;LJI308;CS-2181;2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol;Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-;LJI308 >=98% (HPLC);viability,Ribosomal S6 Kinase (RSK),LJI-308,stimulation,phosphorylation,LJI308,inhibit,mutation,Inhibitor,LJI 308,breaks,double-strand,cancer,S6K |
CAS号 | 1627709-94-7 |
分子式 | C21H18F2N2O2 |
分子量 | 368.38 |
EINECS号 | 604-604-1 |
相关类别 | 抑制剂;细胞生物学试剂 |
Mol文件 | 1627709-94-7.mol |
结构式 |
LJI308 性质
储存条件 | Inert atmosphere,Store in freezer, under -20°C |
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溶解度 | 溶于二甲基亚砜 |
形态 | 结晶固体 |
LJI308 inhibits S6K1 with an IC
50
of 0.8 μM.
LJI308 inhibits YB-1 phosphorylation in CRC cells at concentrations of 5 to 25 μM. In a dose kinetics experiment, LJI308, starting at 2.5 μM, inhibits YB-1 phosphorylation in the KRAS mutated TNBC cell line MDA-MB-231 by approximately 86%. LJI308 effectively blocks RSK and YB-1 phosphorylation after EGF stimulation and after irradiation in KRAS wild-type HBL-100 cells.
LJI308 (1-10 μM; 96 hours) decreases cell viability by up to 90%.
Cell Viability Assay
Cell Line: | HTRY-LT cell lines |
Concentration: | 1-10 μM |
Incubation Time: | 96 hours |
Result: | Decreased cell viability by up to 90%. |
安全信息
海关编码 | 2934999090 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-19713 | LJI308 | 1 mg | 409元 | |
2024/01/25 | HY-19713 | LJI308 LJI308 | 1627709-94-7 | 5mg | 900元 |