PF-CBP1
| 中文名称 | PF-CBP1 |
|---|---|
| 中文同义词 | 化合物PF-CBP1 HYDROCHLORIDE;PF-CBP1盐酸 |
| 英文名称 | PF-CBP1 (hydrochloride) |
| 英文同义词 | PF-CBP1 (hydrochloride);4-[2-[5-(3,5-dimethylisoxazol-4-yl)-2-[2-(4-propoxyphenyl)ethyl]benzimidazol-1-yl]ethyl]morpholine;5-?(3,?5-Dimethyl-?4-?isoxazolyl)?-?1-?[2-?(4-?morpholinyl)?ethyl]?-?2-?[2-?(4-?propoxyphenyl)?ethyl]?-1H-?benzimidazole Hydrochloride;5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole;HFOZCHHWLMTUTP-UHFFFAOYSA-N;parkinson's disease,HATs,cortical,inflammatory,HAT,Histone Acetyltransferase,PF CBP1 hydrochloride,inhibit,RGS4,epilepsy,Epigenetic Reader Domain,PF-CBP1,PFCBP1 hydrochloride,Inhibitor,neurological disorder,PF-CBP-1 hydrochloride,neuron;PF-CBP1 hydrochloride（b） |
| CAS号 | 2070014-93-4 |
| 分子式 | C29H37ClN4O3 |
| 分子量 | 525.09 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2070014-93-4.mol |
| 结构式 |  |
PF-CBP1 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO 中≥52.5 mg/mL；不溶于水；乙醇中≥40.6 mg/mL |
| 形态 | 固体 |
|
CREBBP 125 nM (IC 50 ) |
EP300 363 nM (IC 50 ) |
CBP 0.19 μM (Kd) |
BRD4 20 μM (Kd) |
ITC is the label-free technique for determining K D values, PF-CBP1 is against CBP (K d =0.19 μM) and >105-fold selective over BRD4 (K d >20 μM) by ITC.PF-CBP1 displays greater than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins, it against BRD2-1,BRD3-1, BRD3-2,BRD4-1, BRD4-2, BRDT-1, TAF1-2, and TAF1L-2 with IC 50 values of 1.24 μM, 1.38 μM, 4.22 μM, 1.54 μM, 9.75 μM, 2.44 μM, 3.39 μM and 7.29 μM, respectively.PF-CBP1 (3-10 μM; pretreatment 30 mins; 4 hours) moderately reduces LPS-induced IL-6 and IFN-b expression in the J774 cell at 10 μM. And it decreases IL-1b expression evidently at 3 μM.PF-CBP1 (100 nM-1000 nM;24 hours) significantly reduced RGS4 mRNA levels(49% reduction) relative to vehicle in cortical neuron cells.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-19999A | PF-CBP1 PF-CBP1 hydrochloride | 2070014-93-4 | 5mg | 500元 |
| 2024/04/30 | HY-19999A | PF-CBP1 PF-CBP1 hydrochloride | 2070014-93-4 | 10mg | 750元 |