489416-12-8
中文名称 | 489416-12-8 |
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中文同义词 | 化合物ST-193 |
英文名称 | ST-193 |
英文同义词 | ST-193;1H-Benzimidazol-5-amine, 1-(4-methoxyphenyl)-N-[[4-(1-methylethyl)phenyl]methyl]-;ST193 HYDROCHLORIDE; ST 193 HYDROCHLORIDE;ST-193 hydrochlorid;ST-193,inhibit,Inhibitor,Arenavirus,ST193,ST 193 |
CAS号 | 489416-12-8 |
分子式 | C24H25N3O |
分子量 | 371.47 |
EINECS号 | |
相关类别 | |
Mol文件 | 489416-12-8.mol |
结构式 |
489416-12-8 性质
沸点 | 562.5±60.0 °C(Predicted) |
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密度 | 1.12±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:≥ 150 mg/mL(403.80 mM) |
酸度系数(pKa) | 5.20±0.10(Predicted) |
IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)
ST-193 inhibits LASV pseudotypes with an IC 50 of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC 50 s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM.
ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101441 | 489416-12-8 ST-193 | 489416-12-8 | 5mg | 2900元 |
2024/04/30 | HY-101441 | 489416-12-8 ST-193 | 489416-12-8 | 10mM * 1mLin DMSO | 3200元 |