189699-82-9
| 中文名称 | 189699-82-9 |
|---|---|
| 中文同义词 | 化合物 T15345 |
| 英文名称 | FR-188582 |
| 英文同义词 | FR-188582;1H-Pyrazole, 3-chloro-5-[4-(methylsulfonyl)phenyl]-1-phenyl-;FR 188582,FR188582 |
| CAS号 | 189699-82-9 |
| 分子式 | C16H13ClN2O2S |
| 分子量 | 332.8 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 189699-82-9.mol |
| 结构式 |  |
189699-82-9 性质
| 沸点 | 539.7±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.33±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | -3.80±0.10(Predicted) |
| 颜色 | 浅黄至黄色 |
|
COX-2 17 nM (IC 50 ) |
In a recombinant human cyclooxygenase (COX) enzyme activity, FR-188582 (FR188582) inhibits COX-2 with an IC 50 value of 17 nM, and the inhibition of prostaglandin (PG) E2 formation by FR188582 isover 6000 times more selective for COX-2 than COX-1.
Oral administration of FR-188582 (0.01-3.2 mg/kg) reverses paw edema in adjuvant arthritic rats and shows a therapeutic effect in a dose-dependent manner with ED 50 values (95% C.L.) of 0.074 (0.00021-0.53) and 0.063 (0.0039-0.31) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively. The anti-inflammatory effect of FR-188582 (FR188582) is threefold more potent than that of Indomethacin with ED 50 values (95% C.L.) of 0.24 (0.047-1.8) and 0.20 (0.021-0.79) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-U00146 | 189699-82-9 FR-188582 | 189699-82-9 | 1mg | 3000元 |
| 2024/08/19 | HY-U00146 | 189699-82-9 FR-188582 | 189699-82-9 | 5mg | 6000元 |