酪胺盐酸盐
中文名称 | 酪胺盐酸盐 |
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中文同义词 | N-甲酰-L-甲硫氨酰-L-白氨酰-L苯丙氨酸;N-甲酰基-L-蛋氨酰-L-亮氨酰-L-苯丙氨酸;N-甲酰基-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸;N-FORMYL-L-METHIONYL-L-LEUCYL-L-PHENYLALANINE N-甲酰基-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸;FMLF, 趋化肽;化合物RO 31-8220 MESYLATE;(S)-2-((S)-2-((S)-2-甲酰胺基-4-(甲硫基)丁酰胺基)-4-甲基戊酰胺基)-3-苯基丙酸 |
英文名称 | TYRAMINE HYDROCHLORIDE |
英文同义词 | fMLF;fMLP (misnomer but widely used);TYRAMINE HCL(P);TYRAMINE HCL(RG);N-Formylmethionine Leucyl-Phenylalanine;Chemotactic peptide, fMLF, fMLP (misnomer but widely used), N-Formyl-L-methionyl-L-leucyl-L-phenylalanine;Formyl-L-Met-L-Leu-L-Phe-OH;N-Formyl-L-Met-L-Leu-L-Phe-OH |
CAS号 | 59880-97-6 |
分子式 | C21H31N3O5S |
分子量 | 437.55 |
EINECS号 | 200-462-5 |
相关类别 | 细胞生物学;细胞信号和神经生物学 |
Mol文件 | 59880-97-6.mol |
结构式 |
酪胺盐酸盐 性质
熔点 | 271-274 °C(lit.) |
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沸点 | 269 °C |
密度 | 1.198±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMF:50 mg/mL,澄清,无色 |
酸度系数(pKa) | 3.50±0.10(Predicted) |
形态 | 白色至灰白色冻干固体 |
颜色 | 白色到近乎白色 |
BRN | 2315783 |
序列 | N-Formyl-Met-Leu-Phe-OH |
CAS 数据库 | 59880-97-6(CAS DataBase Reference) |
TNF-alpha
Binding of N-Formyl-Met-Leu-Phe to its specific cell surface receptor, N-formyl peptide receptor (FPR), triggers different cascades of biochemical events, eventually leading to cellular activation. FPR is a chemoattractant receptor belonging to the G protein-coupled receptor family. N-Formyl-Met-Leu-Phe promotes osteoblastic commitment and suppresses adipogenic commitment under osteoblastic differentiation conditions. N-Formyl-Met-Leu-Phe stimulates osteogenesis is associated with increased expression of osteogenic markers and mineralization. N-Formyl-Met-Leu-Phe inhibits expression of peroxisome proliferator-activated receptor-γ1. N-Formyl-Met-Leu-Phe-stimulated osteogenic differentiation is mediated via FPR1-phospholipase C/phospholipase D-Ca 2+ -calmodulin-dependent kinase II-ERK-CREB signaling pathways. N-Formyl-Met-Leu-Phe, a bacterial-derived peptide, induced proinflammatory cytokine gene expression in human peripheral blood monocytes. Bacterial products LPS and N-Formyl-Met-Leu-Phe synergistically induce inflammatory response via multiple signaling pathways. TLR4, IKKβ-IκBα, and NF-κB signaling pathways are involved in the synergistic induction of TNF-α via p65 nuclear translocation-dependent mechanisms.
N-Formyl-Met-Leu-Phe promotes bone formation in zebrafish and rabbits. Extensive skeletal development is evident at 5 dpf in over 80% of N-Formyl-Met-Leu-Phe-treated zebrafish. Treatment with N-Formyl-Met-Leu-Phe results in increased expression of Runx2. Bone marrow spaces are widely formed, and connective tissue covering bone is dense, like periosteum, in N-Formyl-Met-Leu-Phe-treated calvaria. N-Formyl-Met-Leu-Phe mediate release of calprotectin from PMN in vitro . It induces release of calprotectin from PMN in a dose dependent manner. A minimum of 10% of total PMN calprotectin is retained at concentrations of 0.1-10.0 nM of N-Formyl-Met-Leu-Phe.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/16 | F1158 | N-甲酰基-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸 N-Formyl-L-methionyl-L-leucyl-L-phenylalanine | 59880-97-6 | 25mg | 995元 |
2024/01/16 | F1158 | N-甲酰基-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸 N-Formyl-L-methionyl-L-leucyl-L-phenylalanine | 59880-97-6 | 100mg | 2390元 |