ALLOSTERIC WNK KINASE INHIBITOR
| 中文名称 | ALLOSTERIC WNK KINASE INHIBITOR |
|---|---|
| 中文同义词 | 5-氯-2-[2-(甲氨基)-4-噻唑基]-4-吡啶基][4-[(4-氯苯基)甲基]-1-哌嗪基]-甲酮;化合物WNK-IN-11;优选][PERFEMIKER]WNK-IN-11 |
| 英文名称 | Allosteric WNK Kinase Inhibitor , |
| 英文同义词 | ALLOSTERIC WNK KINASE INHIBITOR;Allosteric WNK Kinase Inhibitor ,;WNK-IN-11;WNK-IN-11; WNK IN 11; WNKIN11; WNK INHIBITOR 11; WNK INHIBITOR-11;2123489-30-3;(5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone;Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-;Threonine proteases,inhibit,WNKIN11,Serine proteases,Serine endopeptidases,Inhibitor,Ser/Thr Protease,WNK IN 11 |
| CAS号 | 2123489-30-3 |
| 分子式 | C21H21Cl2N5OS |
| 分子量 | 462.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2123489-30-3.mol |
| 结构式 |  |
ALLOSTERIC WNK KINASE INHIBITOR 性质
| 沸点 | 641.1±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.407±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：30mg/mL； DMF:PBS (pH 7.2) (1:10)：0.1 mg/mL； DMSO：25mg/mL；乙醇：3mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 5.52±0.10(Predicted) |
WNK-IN-11 是一种有效的、具有选择性的 With-No-Lysine (WNK) 的口服活性变构抑制剂，对WNK1酶的IC50为4 nM。
| Target | Value |
|
WNK1
(Cell-free assay) | 4 nM |
WNK-IN-11 (compound 11) shows IC 50 <2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC 50 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-112094 | WNK-IN-11 | 1 mg | 920元 | |
| 2024/01/25 | HY-112094 | ALLOSTERIC WNK KINASE INHIBITOR WNK-IN-11 | 2123489-30-3 | 5mg | 2300元 |