11B-羟孕酮
中文名称 | 11B-羟孕酮 |
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中文同义词 | 11B-羟孕酮;11Β-羟基-4-孕烯-3,20-二酮;11Β-羟基孕-4-烯-3,20-二酮;11Β-羟孕酮, >98%;11Β-羟孕酮(溶液);11Β-羟孕酮;11Β-羟基黄体酮;化合物 TCA2511 |
英文名称 | 11BETA-HYDROXYPROGESTERONE |
英文同义词 | 11-beta-hydroxy-pregn-4-ene-20-dione;11-beta-hydroxypregn-4-ene-3,20-dione;11-hydroxy-20-dion(11-beta)-pregn-4-ene-;21-deoxycorticosterone;HYDROXYPROGESTERONE, 11B-;17-acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one;4-PREGNEN-11BETA-3,20-DIONE;4-PREGNEN-11BETA-OL-3,20-DIONE |
CAS号 | 600-57-7 |
分子式 | C21H30O3 |
分子量 | 330.46 |
EINECS号 | 209-995-8 |
相关类别 | 标准品 -中药标准品;Steroids |
Mol文件 | 600-57-7.mol |
结构式 |
11B-羟孕酮 性质
熔点 | 181~184℃ |
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沸点 | 487.4±45.0 °C(Predicted) |
密度 | 1.15±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 可溶于丙酮(少许)、氯仿(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 14.52±0.70(Predicted) |
颜色 | 白色至类白色 |
水溶解性 | 30.84mg/L(37 ºC) |
Human Endogenous Metabolite
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11OHP displays agonist mineralocorticoid activity. 11β-hydroxyprogesterone activates the transiently expressed hMR in COS-7 cells in a dose-dependent manner with an ED 50 of 10 nM and stimulates Ams/ sc in mpkCCD cl4 cells. Docking 11β-hydroxyprogesterone within the hMR-ligand-binding domain homology model reveals that the agonist activity of 11OHP is caused by contacts between its 11β-hydroxyl group and Asn770.
11β-hydroxyprogesterone causes a significant elevation in blood pressure within 3 days, an effect that persisted throughout the 14-day infusion. 11β-hydroxyprogesterone is potently hypertensinogenic in the rat and that this activity depends on an intact adrenal and at least in part on the activation of mineralocorticoid receptors.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N2337 | 11beta-Hydroxyprogesterone | 1 mg | 225元 | |
2024/08/19 | HY-N2337 | 11B-羟孕酮 11beta-Hydroxyprogesterone | 600-57-7 | 5mg | 450元 |