| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:NeMonapride
CAS:75272-39-8
Package:100Mg,10Mg,2.5Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:NeMonapride;cis-5-Chloro-2-Methoxy-4-(MethylaMino)-N-[2-Methyl-1-(phenylMethyl)-3-pyrrolidinyl]benzaMide
CAS:75272-39-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | NEMONAPRIDE Basic information |
| | NEMONAPRIDE Chemical Properties |
| Melting point | 152-153°C | | storage temp. | Store at RT | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | CAS DataBase Reference | 75272-39-8 |
| | NEMONAPRIDE Usage And Synthesis |
| Description | Nemonapride is a potent dopamine D2receptor antagonist antipsychotic reported to
have superior efficacy against hallucinations and delusions and also to be effective in
the treatment of negative symptoms. The compound is a benzamide diastereomer and,
although more potent than haloperidol, side effects are reported to be few primarily
akinesia and some muscle rigidity with extrapyramidal symptoms being rare. | | Description | Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals. It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively). Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM). | | Chemical Properties | Colourless Crystalline Solid | | Originator | Yamanouchi (Japan) | | Uses | Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic. | | Uses | A selective dopamine D2 receptor antagonist. Used as an antipsychotic | | Definition | ChEBI: (2R,3R)-nemonapride is an optically active form of nemonapride having (2R,3R)-configuration. It is a conjugate base of a (2R,3R)-nemonapride(1+). It is an enantiomer of a (2S,3S)-nemonapride. | | Brand name | Emirace | | Biological Activity | Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors. | | storage | Store at RT |
| | NEMONAPRIDE Preparation Products And Raw materials |
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