甘珀酸钠
| 中文名称 | 甘珀酸钠 |
|---|---|
| 中文同义词 | 甘珀酸钠;甘珀酸 二钠盐;氢琥珀酸甘草次酸;卡柏若克索龙;氢琥珀酸甘草次酸二钠盐;18β-甘草次酸半琥珀酸酯二钠;18Β-甘草次酸半琥珀酸酯二钠 |
| 英文名称 | Carbenoxolone disodium |
| 英文同义词 | (3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OIC ACID 3-HEMISUCCINATE) DISODIUM SALT;CARBENOXOLONE DISODIUM SALT;CARBENOXOLONE SODIUM;18-beta-glycyrrhetinicacidhydrogensuccinate,disodiumsalt;20-beta)-3-bet;3-beta-hydroxy-11-oxoolean-12-en-30-oicacidhydrogensuccinate,disodiumsal;3-o-(beta-carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oicacid,disodium;disodiumglycyrrhetinylsuccina |
| CAS号 | 7421-40-1 |
| 分子式 | C34H48Na2O7 |
| 分子量 | 614.72 |
| EINECS号 | 231-044-0 |
| 相关类别 | 小分子抑制剂;标准品;中药对照品;原料;OPTAFLEXX;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous;Steroids |
| Mol文件 | 7421-40-1.mol |
| 结构式 |  |
甘珀酸钠 性质
| 熔点 | >275°C (dec.) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | pKa1 4.18; pKa2 5.52(at 25℃) |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in water to 100 mM. |
| 稳定性 | 吸湿性 |
| LogP | 7.083 (est) |
| CAS 数据库 | 7421-40-1(CAS DataBase Reference) |
IC50: human 11β-HSD; bacterial 3α, 20β-HSD; gap junction; Vaccinia virus
Carbenoxolone disodium (6-150 μM; pre-treatment 1 hour) inhibits Vaccinia virus (VACV) replication in a gap junction-independent in HaCaT cells, and it has toxicity effects on VACV-A5L-EGFP infected cells at 48 h.Carbenoxolone (30 μM; pre-treatment 1 hour) does not upregulate PP2A expression, but induces the late protein A27 expression in hacat cells.
Cell Viability Assay
| Cell Line: | HaCaT cells |
| Concentration: | 6 μM, 12 μM, 30 μM, 60 μM, 150 μM |
| Incubation Time: | Pre-treatment 1 hour |
| Result: | Had no toxicity until 48 hours at high dose in virus-infected cells. |
Western Blot Analysis
| Cell Line: | HaCaT cells |
| Concentration: | 30 μM |
| Incubation Time: | Pre-treatment 1 hour |
| Result: | Presented an obvious upregulation of A27. |
Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Diazepam) does not induce a muscle relaxant activity and shows muscle relaxant activity compared to normal saline, and this effect was more than diazepam in the traction test.Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Pentylenetetrazole) significantly increases sleeping time and decreases latency in mice as a dose-dependent manner in Pentylenetetrazole (PTZ) Seizure model. The ED 50 value is 83.3 mg/kg (%95 CL:556.29).
| Animal Model: | Male BALB/c mice |
| Dosage: | 100, 200 and 300 mg/kg |
| Administration: | Intraperitoneal injection; 30, 60 and 60 min before Pentylenetetrazole |
| Result: | Significantly increased the sleeping time in mice. |
安全信息
| 提供商 | 语言 |
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英文
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