4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐

4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐

中文名称4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐
中文同义词4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐;((4-氨基苯基)磺酰基)(6-氯吡嗪-2-基)酰胺钠
英文名称sodium N-(6-chloropyrazinyl)sulphanilamidate
英文同义词sodium N-(6-chloropyrazinyl)sulphanilamidate;Sulfaclozine sodium monohydrate;4-Amino-N-(6-chloro-2-pyrazinyl)benzenesulfonamide sodium salt;Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide;Sulfaclozine (sodium salt)
CAS号23307-72-4
分子式C10H10ClN4NaO2S
分子量308.72
EINECS号245-571-9
相关类别
Mol文件23307-72-4.mol
结构式4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐 结构式

4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐 性质

储存条件under inert gas (nitrogen or Argon) at 2–8 °C
溶解度DMF:1mg/mL; DMSO:1mg/mL; PBS(pH 7.2):1 mg/mL

4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐 用途与合成方法

Sulfaclozine sodium (Sulfachloropyrazine sodium) 是一种有效的磺酰胺衍生物,具有抗菌和抗球虫作用。Sulfaclozine sodium 通常用于各种家禽疾病(尤其是结肠杆菌病,禽霍乱和球虫病)的相关研究。

Bacterial; Parasite

The elimination of Sulfaclozine in the three systems: UV/TiO 2 , UV/K 2 S 2 O 8 , and UV/TiO 2 /K 2 S 2 O 8 . Sulfaclozine is weakly adsorbed on the surface of TiO 2 at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO 2 , UV/K 2 S 2 O 8 , and UV/TiO 2 /K 2 S 2 O 8 in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of OH and SO 4 •− radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals.

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections.

Animal Model: 14 male broiler chickens (30-day-old)
Dosage: 60 mg/kg
Administration: Intravenous injection or oral administration (Pharmacokinetic Analysis)
Result: Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.

安全信息

WGK Germany3

MSDS信息

4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐 上下游产品信息

"4-氨基-N-(6-氯-2-吡嗪基)苯磺酰胺钠盐"相关产品信息
磺胺氯达嗪钠 氟苯尼考 地克珠利
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