1,2:5,6-二脱水半乳糖醇
中文名称 | 1,2:5,6-二脱水半乳糖醇 |
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中文同义词 | 1,2:5,6-二脱水半乳糖醇;卫矛醇二环氧化物;去水卫矛醇;VAL-083,烷化剂 |
英文名称 | Dianhydrogalactitol |
英文同义词 | Dianhydrogalactitol;Dianhydrodulcitolum;1,2,5,6-DIANHYDRODULCITOL;1,2:5,6-Diepoxyhexane-3,4-diol;1,2-Di(oxiranyl)ethylene glycol;Dulcitol diepoxide;NSC-132313;1,2:5,6-Diepoxydulcitol |
CAS号 | 23261-20-3 |
分子式 | C6H10O4 |
分子量 | 146.14 |
EINECS号 | |
相关类别 | 细胞周期;标准品;中药对照品;APIS |
Mol文件 | 23261-20-3.mol |
结构式 |
1,2:5,6-二脱水半乳糖醇 性质
熔点 | 96.5-98.5 °C |
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沸点 | 185.74°C (rough estimate) |
密度 | 1.567 |
折射率 | 1.4310 (estimate) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 粉末 |
酸度系数(pKa) | 13.53±0.20(Predicted) |
DNA Alkylator
VAL-083 is an alkylating agent that creates N7 methylation on DNA. VAL-083 suppresses U251 and SF188 cell growth and induces apoptosis after 72 h. VAL-083 (5 μM) inhibits the growth of SF188 by ∼95%. VAL-083 inhibits T98G cells growth in a dose-dependent manner (IC 50 <5 μM). VAL-083 (Dianhydrogalactitol) inhibits the proliferation of HUVEC and U251 cells at doses of more than 12.5 μg/mL. VAL-083 (3.125, 6.25, 12.5 μg/mL) also suppresses the migration and invasion, and reduces MMP2, VEGF, VEGFR2, and FGF2 expression in HUVEC and U251 cells. VAL-083 (1,2:5,6-dianhydrogalactitol, 1, 2, 5 μM) dose-dependently induces cell cycle arrest at G2/M phase in the 3 glioma cell lines. VAL-083 activates two parallel signaling cascades, the p53-p21 and the CDC25C-CDK1 cascade. In addition, VAL-083 significantly enhances the radiosensitivity of LN229 cells.
VAL-083 (Dianhydrogalactitol; 25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in zebrafish model. VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes reduction in FGFR2 expression at 50 μg/mL. VAL-083 (1,2:5,6-dianhydrogalactitol; 5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58%. Moreover, VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor moedl.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-16513 | VAL-083 | 1 mg | 800元 | |
2024/04/30 | HY-16513 | 1,2:5,6-二脱水半乳糖醇 VAL-083 | 23261-20-3 | 5mg | 1600元 |