喷曲肽
| 中文名称 | 喷曲肽 |
|---|---|
| 中文同义词 | 喷曲肽;化合物 T16469 |
| 英文名称 | Pentetreotide |
| 英文同义词 | Pentetreotide;CA index name: L-Cysteinamide, N-[2-[[2-bis(carboxymethyl)amino]-ethyl](carboxymethyl)amino]ethyl]-N-(carboxymethyl)glycyl-;DTPA-octreotide;DTPA-SMS;L-Cysteinamide, N-[2-[[2-bis(carboxymethyl)amino]-ethyl](carboxymethyl)amino]ethyl]-N-(carboxymethyl)glycyl- D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl- L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (3-8)-disulfide;Pentreotide;[DTPA-D-Phe1]octreotide;N-[2-[[2-[Bis(carboxymethyl)amino]ethyl](carboxymethyl)amino]ethyl]-N-(carboxymethyl)-Gly-D-Phe-L-Cys(1)-L-Phe-D-Trp-L-Lys-L-Thr-L-Cys(1)-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-NH2 |
| CAS号 | 138661-02-6 |
| 分子式 | C63H87N13O19S2 |
| 分子量 | 1394.57 |
| EINECS号 | |
| 相关类别 | 化工原料 |
| Mol文件 | 138661-02-6.mol |
| 结构式 |  |
喷曲肽 性质
| 沸点 | 1717.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.47 |
| 酸度系数(pKa) | 1.67±0.10(Predicted) |
Pentetreotide 是 Octreotide 的 DTPA 共轭物。Pentetreotide 是一种铟标记的生长抑素类似物，可用于核医学成像。Pentetreotide 与生长抑素受体闪烁显影可有效观察神经内分泌肿瘤及其转移。
Neuroendocrine tumors have an increased number of somatostatin receptors, as compared to normal tissues. At present time, there are five known subtypes. Somatostatin receptor scintigraphy with 111 In-Pentetreotide binds to two of these subtypes and is effective in visualizing neuroendocrine tumors, and its metastasis with an overall diagnostic sensitivity of 70% to 90%. It is considerably more sensitive than conventional anatomic imaging. Its usage in neuroendocrine tumors not only includes assessment of disease extent, but also in identified primary lesion, assesses treatment response, and selection for radionuclide therapy.