|
|
| | PROCATEROL HYDROCHLORIDE Basic information |
| Product Name: | PROCATEROL HYDROCHLORIDE | | Synonyms: | Procaterol hydrochlorid;erythro-8-hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]-2(1h)-quinolinone;2(1H)-Quinolinone, 8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, monohydrochloride, rel- (9CI);2(1H)-Quinolinone, 8-hydroxy-5-[1-hydroxy-2-[(1-methylethyl)amino]butyl]-, monohydrochloride, (R*,S*)-;2(1H)-Quinolinone, 8-hydroxy-5-[1-hydroxy-2-[(1-methylethyl)amino]butyl]-, monohydrochloride, (R*,S*)-(+-)-;PROCATEROL HCL;5-(1-hydroxy-2-isopropylamino)butyl-8-hydroxycarbostyrilhydrochloride;8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1h)-quinolinonmono | | CAS: | 62929-91-3 | | MF: | C16H23ClN2O3 | | MW: | 326.82 | | EINECS: | 263-763-0 | | Product Categories: | Adrenoceptor | | Mol File: | 62929-91-3.mol |  |
| | PROCATEROL HYDROCHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | Soluble to 100 mM in water and to 100 mM in DMSO | | form | Powder | | Stability: | Hygroscopic |
| WGK Germany | 2 | | RTECS | VC8296000 |
| | PROCATEROL HYDROCHLORIDE Usage And Synthesis |
| Description | Procaterol is an agonist of β2-adrenergic receptors (β2-ARs). It binds to (Kd = 46 pM), and is selective for, β2-ARs over β1-ARs (Kd = 4,000 pM). Procaterol binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (; IC50s = 55.1 and 1,660 nM, respectively). It inhibits contractions induced by acetylcholine in isolated guinea pig trachea (EC50 = 10.5 nM). In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 μg/ml. | | Uses | adrenergic agonists | | Uses | Procaterol Hydrochloride is a short-acting pulmonary β2-agonist for asthma treatment. | | General Description | Procaterol is used to prevent lung fibroblast migration. It has anti-inflammatory properties. It can block type 2 T helper (Th2)-related chemokine production in human monocytes and bronchial epithelial cells. | | Biological Activity | Specific and very potent β 2 agonist. | | Biochem/physiol Actions | β2-adrenoceptor agonist; bronchodilator. | | storage | Store at RT |
| | PROCATEROL HYDROCHLORIDE Preparation Products And Raw materials |
|