替达霉素A
| 中文名称 | 替达霉素A |
|---|---|
| 中文同义词 | 替达霉素A;提朗达霉素 |
| 英文名称 | TIRANDAMYCIN |
| 英文同义词 | TIRANDAMYCIN;tirandamycin A;3-[(1E,2E,4E,6R)-1-Hydroxy-4-methyl-6-[(1S,4α,6S)-1,2α,7α-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]decan-8β-yl]-2,4-heptadien-1-ylidene]-2,4-pyrrolidinedione;2,4-Pyrrolidinedione, 3-[(2E,4E,6R)-1-hydroxy-4-methyl-6-[(1S,2S,4R,6S,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]dec-8-yl]-2,4-heptadienylidene]-, (3E)- (9CI) |
| CAS号 | 34429-70-4 |
| 分子式 | C22H27NO7 |
| 分子量 | 417.45 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 34429-70-4.mol |
| 结构式 |  |
替达霉素A 性质
| 沸点 | 639.1±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.307±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 6?+-.0.20(Predicted) |
Tirandamycin A, 一种抗生素， 是一种细菌 RNA 聚合酶 (bacterial RNA polymerase) 抑制剂。Tirandamycin A 具有抗阿米巴原虫和抗菌性能。
A 60 μM treatment with Tirandamycin A results in a slightly stronger inhibition, demonstrating a 84.2% reduction in growth of Entamoeba histolytica HM-1:IMSS and 64.8% reduction in growth by Entamoeba histolytica Col. Tirandamycin A inhibits chain initiation and elongation of bacterial RNA polymerase without acting on mammalian polymerases.