(2-MERCAPTOETHYL)-GUANIDINE SULFATE
| 中文名称 | (2-MERCAPTOETHYL)-GUANIDINE SULFATE |
|---|---|
| 中文同义词 | (2-巯基乙基)-胍硫酸盐 |
| 英文名称 | (2-MERCAPTOETHYL)-GUANIDINE SULFATE |
| 英文同义词 | (2-MERCAPTOETHYL)-GUANIDINE SULFATE;MEG SULFATE;meg hemisulfate salt;mercaptoethylguanidine hemisulfate salt;1-?(2-?Mercaptoethyl)?guanidine Sulfate;XJKZAAUVINNNNC-UHFFFAOYSA-N |
| CAS号 | 3979-00-8 |
| 分子式 | C3H11N3O4S2 |
| 分子量 | 217.26714 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 3979-00-8.mol |
| 结构式 |  |
(2-MERCAPTOETHYL)-GUANIDINE SULFATE 性质
| 熔点 | 177-178 °C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | PBS (7.2): 10 mg/mL |
| 形态 | 结晶固体 |
IC50: 11.5 μM (iNOS), 110 μM (ecNOS), 60 μM (bNOS)
MEG (0.1-1000 μM; 18 h) reduces nitrite accumulation in the supernatant of cultured J774.2 macrophages activated with LPS (10 μg/mL) and INF (50 μg/mL). MEG inhibits iNOS activity in homogenates of lungs taken from LPS-treated rats.
MEG (1 μM-3 mM; 3 min) dose-dependently inhibits the peroxynitrite-induced oxidation of cytochrome c
2+
and hydroxylation of benzoate.
MEG (1-300 μM) inhibits the suppression of mitochondrial respiration and DNA single strand breakage in response to peroxynitrite in J774 cells.
MEG (300 μM; 30 min) inhibits the suppression of vascular contractility in response to peroxynitrite in thoracic aortic rings.
MEG (10 mg/kg; i.p. for 5 d) attenuates the degree of lipid peroxidation, protein oxidation, and peroxynitrites level and ameliorated the decrease of antioxidant enzymes activities in the esophagus of rats subjected to caustic burn injury.
MEG (30-60 mg/kg; a single i.p.) decreases mean arterial blood pressure (MAP) of normal rats.
MEG (10 mg/kg; a single i.p.) improves the renal dysfunction and tissue injury induced by ischemia/reperfusion (I/R) of rat kidney.
| Animal Model: | Sprague-Dawley rats (200-250 g) were injured the esophagus |
| Dosage: | 10 mg/kg |
| Administration: | I.p. for 5 days |
| Result: |
Reduced the stenosis index (SI) and the histopathologic damage score.
Decreased the malondialdehyde and protein carbonyl content and increased the activities of superoxide dismutase and glutathione peroxidase. Regulated the nitrate and nitrite level. |
安全信息
| WGK Germany | 3 |
|---|