OXOTREMORINE

OXOTREMORINE Suppliers list
Company Name: Nanjing Bicbiotechnology Co., Ltd
Tel: +86-2552131256 +86-18251840740
Email: sales@bicbiotech.com
Products Intro: Product Name:OXOTREMORINE
CAS:70-22-4
Purity:95.0% Package:500mg;1g;5g;10g;25g
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:OXOTREMORINE
CAS:70-22-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Shaanxi DIDU pharmaceutical and Chemical Co., Ltd  
Tel: 15229059051
Email: 1027@dideu.com
Products Intro: Product Name:OXOTREMORINE
CAS:70-22-4
Purity:99% HPLC Package:25kg;1kg
Company Name: Nanjing Bic Biotechnology Co., Ltd  
Tel: 025-58906079
Email: sales@bicbiotech.com
Products Intro: Product Name:OXOTREMORINE
CAS:70-22-4
Purity:95.0% Package:500mg;1g;5g;10g;25g
Company Name: Riedel-de Haen AG  
Tel: 800 558-9160
Email:
Products Intro: CAS:70-22-4
OXOTREMORINE Basic information
Product Name:OXOTREMORINE
Synonyms:2’-oxopyrrolidino-1-pyrrolidino-4-butyne;oxotremorin;1-(4-(pyrrolidin-1-yl)but-2-ynyl)pyrrolidin-2-one;1-(2-Oxo-pyrrolidin-1-yl)-4-(pyrrolidin-1-yl)-2-butyne;1-(2-Oxopyrrolidin-1-yl)-4-(pyrrolidin-1-yl)-2-butyne;1-[4-(Pyrrolidin-1-yl)-2-butynyl]pyrrolidin-2-one;1-(4-pyrrolidin-1-ylbut-2-ynyl)-2-pyrrolidone;1-(4-(Pyrrolidin-1-yl)but-2-yn-1-yl)pyrrolidin-2-one
CAS:70-22-4
MF:C12H18N2O
MW:206.28
EINECS:200-728-0
Product Categories:
Mol File:70-22-4.mol
OXOTREMORINE Structure
OXOTREMORINE Chemical Properties
Melting point <25 °C
Boiling point 124 °C0.1 mm Hg(lit.)
density 1 g/mL at 25 °C(lit.)
refractive index n20/D 1.517(lit.)
Fp 113 °C
storage temp. 2-8°C
solubility H2O: 50 mg/mL
form liquid
pka8.29±0.20(Predicted)
color clear, light yellow
Merck 13,7020
Safety Information
Hazard Codes T+,C
Risk Statements 28-34
Safety Statements 26-36/37/39-45
RIDADR UN 2810 6.1/PG 1
WGK Germany 3
RTECS UY5950100
10-23
HazardClass 6.1(a)
PackingGroup I
ToxicityLD50 ipr-rat: 4400 mg/kg TXAPA9 14,67,69
MSDS Information
ProviderLanguage
SigmaAldrich English
OXOTREMORINE Usage And Synthesis
DefinitionChEBI: Oxotremorine is a N-alkylpyrrolidine.
General DescriptionOxotremorine [1-(-pyrrolidono)-4-pyrrolidino-2-butyne] has been regarded as a CNS muscarinicstimulant. Its action on the brain produces tremors inexperimental animals. It increases ACh brain levels in ratsup to 40% and has been studied as a drug in the treatment ofAlzheimer disease. Although earlier studies suggested thatthis approach of elevating levels of ACh to treat Alzheimerdisease is useful, this belief was highly disputed by manyresearchers.
Clinical UseNevertheless, oxotremorine, as a cholinergicagonist, facilitates memory storage. These findings haveserved as important leads in the development of agents usefulin treating Alzheimer disease. Although it possessesgroups that do not occur in other highly active muscarinicagents, oxotremorine’s trans conformation shows that distancesbetween possible active centers correspond with (+)-muscarine.
Safety ProfilePoison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx.
OXOTREMORINE Preparation Products And Raw materials
Tag:OXOTREMORINE(70-22-4) Related Product Information
Diethylacetamide N,N-Dimethylacetamide N,N-Dimethylformamide PROPARGYLAMINE 1-Methylpyrrolidine 1-PROP-2-YN-1-YLPYRROLIDINE 2-Pyrrolidinone N,N-Dimethylpropionamide 2-Butyne N,N-Diethylpropargylamine OXOTREMORINE N,N-Diethylformamide 1-DIMETHYLAMINO-2-PROPYNE N-METHYLPROPARGYLAMINE 1-Ethyl-2-pyrrolidone N-ETHYLPROPIONAMIDE 1-PROP-2-YNYL-PYRROLIDIN-2-ONE N-ETHYLPYRROLIDINE