ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Adrenal corticosteroids >Triamcinolone acetonide

Triamcinolone acetonide

Triamcinolone acetonide Suppliers list
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Products Intro: Product Name:Triamcinolone Acetonide
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Products Intro: Product Name:Triamcinolone acetonide
Purity:99% Package:1Kg;25kg/ Drum or as customer request
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:76-25-5
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Products Intro: Product Name:Triamcinolone acetonide
Purity:99.9% Package:1KG;100USD
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Products Intro: Product Name:Triamcinolone Acetonide
Purity:98% Package:1g/5g

Lastest Price from Triamcinolone acetonide manufacturers

Triamcinolone acetonide Basic information
Appearance and properties Glucocorticoid drugs Uses Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage Characteristics Extinguishing agent
Product Name:Triamcinolone acetonide
Product Categories:NASACORT;Steroid and Hormone;Biochemistry;Steroids;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:76-25-5.mol
Triamcinolone acetonide Structure
Triamcinolone acetonide Chemical Properties
Melting point 274-278°C (dec.)
alpha D23 +109° (c = 0.75 in chloroform)
Boiling point 576.9±50.0 °C(Predicted)
density 1.1517 (estimate)
refractive index 1.5980 (estimate)
storage temp. Refrigerator
solubility Practically insoluble in water, sparingly soluble in ethanol (96 per cent).
form neat
Water Solubility Soluble in DMSO or ethanol. Slightly soluble in water.
Merck 9596
Stability:Combustible. Incompatible with strong oxidizing agents.
NIST Chemistry ReferenceTriamcinolone acetonide(76-25-5)
EPA Substance Registry SystemTriamcinolone acetonide (76-25-5)
Safety Information
Hazard Codes T
Risk Statements 61
Safety Statements 53-45
WGK Germany 3
RTECS TU3920000
HS Code 29372290
ToxicityLD50 oral in mouse: 5gm/kg
Triamcinolone acetonide Usage And Synthesis
Appearance and propertiesTriamcinolone acetonide, its acetate form appears to be white or white-like crystalline powder. The drug is odorless, with bitter taste. It is hardly soluble in water, slightly soluble in ethanol, soluble in chloroform, and slightly soluble in acetone.
Glucocorticoid drugsTriamcinolone acetonide is a kind of long-term glucocorticoid drugs which is now widely used in clinical Dermatology of China. It belongs to adrenocorticotropic hormone drugs. It is the derivative of Triamcinolone, and with the same function as Triamcinolone. Triamcinolone acetonide functions in anti-inflammatory, anti-allergic, anti-itching and shrinking capillaries. What’s more, besides its weak water-sodium retention, the effect of Triamcinolone acetonide for anti-inflammatory, anti-allergic is much stronger and more durable than hydrocortisone (10 to 30 folds), and prednisone. It can also treat bronchial asthma by aerosol inhalation with very strong and durable effect. Triamcinolone acetonide has better efficacy on local treatment compared with triamcinolone. It is Oral absorbed easily. Taking orally 5mg of the drug yields a bioavailability of about 23%. Its plasma concentration reaches peak (105 ng/mL) within one hour with the half-life is being 2 hours; It has a slow intramuscular absorption rate which takes effect within hours, and gives maximal effect within 1 to 2 days. The effect can be maintained for 2~3 weeks; the absorption rate of intradermal and intra-articular injection of the drug is low, but has a long-lasting effect; generally the efficacy can be maintained for more than 1-2 week per injection. This product has a low binding rate with plasma albumin protein, and is metabolized into non-active product in the liver, kidneys and tissues which is then further excreted by the kidneys. It also has a long-lasting effect upon local injection. Moreover, topical ointments can also produce a good effect. Clinically triamcinolone acetonide is used for treatment of various skin diseases such as atopic dermatitis, contact dermatitis, seborrheic dermatitis, neurodermatitis, eczema, psoriasis, psoriasis, lichen planus and skin pruritus, as well as bronchial asthma, rheumatoid arthritis, acute sprains, chronic ache in back and legs, frozen shoulder, tenosynovitis, ophthalmic inflammation, oral mucosal congestion, erosion, ulcers, granulomatous cheilitis, and oral mucosa chronic infectious diseases, Furthermore, it can also be used for local injection treatment in keloid, cystic acne, discoid lupus erythematosus, alopecia areata and other small area of damages. Triamcinolone acetonide nasal spray can be used for the prevention and treatment of perennial, seasonal allergic rhinitis, and vasomotor rhinitis. Intra-articular injection of this drug can eliminate inflammation and pain, swelling or can alleviate, pain, stiffness and swelling feeling.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
UsesIt is adrenal cortex hormones drugs used for treating diseases such as neurodermatitis, eczema, psoriasis, joint pain, and asthma.
CategoryToxic Substances.
Toxicity gradingHighly toxic.
Acute toxicitySubcutaneous-rat LD50: 13.1 mg/kg; intraperitoneal-Mouse LD50: 105 mg/kg.
Flammability hazard characteristicsCombustible; combustion produces toxic fumes of fluoride.
Storage CharacteristicsTreasury: ventilation, low-temperature and dry; store separately from food raw materials.
Extinguishing agentDry powder, foam, sand, carbon dioxide, water spray.
Chemical PropertiesWhite Solid
UsesA glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal).
UsesTriamcinolone acetonide is a topical and systemic corticosteroid belonging to the group-B (triamcinolone acetonide) type of steroids.
IndicationsTriamcinolone acetonide (Aristocort, Kenalog) is a synthetic fluorinated corticosteroid.
DefinitionChEBI: A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.
Manufacturing ProcessA solution of 250 mg of 9α-fluoro-11β,16α,17α,21-tetrahydroxy-1,4- pregnadiene-3,20-dione in 70 ml of hot acetone and 7 drops of concentrated hydrochloric acid is boiled for 3 minutes. After standing at room temperature for 17 hours, the reaction mixture is poured into dilute sodium bicarbonate and extracted with ethyl acetate. The extract is washed with saturated saline solution, dried and evaporated to a colorless glass. The residue is crystallized from acetone-petroleum ether to afford 166 mg of the acetonide, MP 270° to 274°C, decomposition, (with previous softening and browning). Three recrystallizations from acetone-petroleum ether give 113 mg of 9α-fluoro- 11β,21-dihydroxy-16α,17α-isopropylidenedioxy-1,4-pregnadiene-3,20-dione, MP 274° to 279°C, decomposition, (with previous softening and browning).
Therapeutic FunctionGlucocorticoid
General DescriptionThe three main metabolitesof triamcinolone acetonide (Azmacort, Nasacort) are 6β-hydroxytriamcinolone acetonide, 21-carboxytriamcinoloneacetonide, and 6β-hydroxy-21-carboxytriamcinolone acetonide.All are much less active than the parent compound.The 6β-hydroxyl group and the 21-carboxy group are bothstructural features that greatly reduce GC action. The increasedwater solubility of these metabolites also facilitatesmore rapid excretion.
General DescriptionTriamcinolone acetonide is approximately 8 times morepotent than prednisone in animal inflammation models.Topically applied triamcinolone acetonide is a potent antiinflammatoryagent, about 10 times more sothan triamcinolone. The plasma half-life is approximately 90minutes, although the plasma half-life and biological halflivesfor GCs do not correlate well. The hexacetonide isslowly converted to the acetonide in vivo and is given onlyby intra-articular injection. Only triamcinolone and the diacetateare given orally. The acetonide and diacetate may begiven by intra-articular or intrasynovial injection. In addition,the acetonide may be given by intrabursal or, sometimes,IM or subcutaneous injection. A single IM dose of thediacetate or acetonide may last up to 3 or 4 weeks. Plasmalevels with IM doses of the acetonide are significantly higherthan with triamcinolone itself. The acetonide is also used totreat asthma and allergic rhinitis.
Clinical UseTriamcinolone acetonide frequently is used by inhalation for the treatment of lung diseases (e.g., asthma).
Safety ProfilePoison by subcutaneous and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and toxic fumes of F-.
Veterinary Drugs and TreatmentsThe systemic veterinary labeled product (Vetalog? Injection) is labeled as “indicated for the treatment of inflammation and related disorders in dogs, cats, and horses. It is also indicated for use in dogs and cats for the management and treatment of acute arthritis, allergic and dermatologic disorders.”
Glucocorticoids have been used in an attempt to treat practically every malady that afflicts man or animal, but there are three broad uses and dosage ranges for use of these agents. 1) Replacement of glucocorticoid activity in patients with adrenal insufficiency, 2) as an antiinflammatory agent, and 3) as an immunosuppressive. Among some of the uses for glucocorticoids include treatment of: endocrine conditions (e.g., adrenal insufficiency), rheumatic diseases (e.g., rheumatoid arthritis), collagen diseases (e.g., systemic lupus), allergic states, respiratory diseases (e.g., asthma), dermatologic diseases (e.g., pemphigus, allergic dermatoses), hematologic disorders (e.g., thrombocytopenias, autoimmune hemolytic anemias), neoplasias, nervous system disorders (increased CSF pressure), GI diseases (e.g., ulcerative colitis exacerbations), and renal diseases (e.g., nephrotic syndrome). Some glucocorticoids are used topically in the eye and skin for various conditions or are injected intra-articularly or intra-lesionally. The above listing is certainly not complete.
MetabolismTriamcinolone acetonide frequently is used by inhalation for the treatment of lung diseases (e.g., asthma). After inhalation, triamcinolone acetonide can become systemically available when the inhaled formulation is swallowed and absorbed unchanged from the GI tract, causing undesirable systemic effects. Triamcinolone acetonide that is swallowed is metabolized to 6β-hydroxytriamcinolone acetonide, 21-carboxytriamcinolone acetonide, and 21-carboxy-6β-hydroxytriamcinolone acetonide, all of which are more hydrophilic than their parent drug. Only approximately 1% of the dose was recovered from the urine as triamcinolone acetonide. Triamcinolone is not a major metabolite of triamcinolone acetonide in humans, suggesting that acetonide is resistant to hydrolytic cleavage. Triamcinolone acetonide is approximately eight times more potent than prednisolone.
Triamcinolone acetonide Preparation Products And Raw materials
Raw materialsAcetone-->Triamcinolone
Tag:Triamcinolone acetonide(76-25-5) Related Product Information
FLUOCINONIDE, [3H]- Triamcinolone acetonide 21-(benzoyl-b-aminoisobutyrate),Triamcinolone acetonide benzoyl-b-aminoisobutyrate Triamcinolone hexacetonide triamcinolone furetonide TRIAMCINOLONE ACETONIDE, [3H]- AMCINONIDE amcinafal flumoxonide Fluocinolone acetonide Triamcinolone acetonide fluoro jade 1-Hydroxyethylidene-1,1-diphosphonic acid Hydroxyethyl Cellulose Hydroxy silicone oil Triamcinolone acetonide 21-acetate Ethyl maltol Hydroxyethyl starch Triamcinolone