衣霉素
| 中文名称 | 衣霉素 |
|---|---|
| 中文同义词 | 衣霉素复合物;TUNICAMYCIN 衣霉素;衣霉素;源于STREPTOMYCESLYSOSUPERFIUSNOV.SP.的链病毒菌素;链病毒菌素;衣霉素 来源于链霉菌属;TUNICAMYCIN FROM STREPTOMYCES SP. 来源于链霉菌 属;衣霉素(链霉菌属) |
| 英文名称 | TUNICAMYCIN |
| 英文同义词 | Aids010655;Aids-010655;Nsc177382;TunicaMycin froM StreptoMyces lysosuperficus;TunicaMycin coMplex;InSolution? Tunicamycin,;TUNICAMYCIN, STREPTOMYCES IYSOSUPERFICUS;TUNICAMYCIN, STREPTOMYCES LYSOSUPERFICUS |
| CAS号 | 11089-65-9 |
| 分子式 | C37H60N4O16 |
| 分子量 | 816.89 |
| EINECS号 | 601-012-4 |
| 相关类别 | 微生物代谢物;细胞信号和神经生物学;细胞生物学;抗生素;抗生素及抗病毒;抗生素、生物碱;生化试剂;对照品;NucleosidesMore...Close...;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics T-ZAntibiotics;AntifungalAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;AntiviralAntibiotics;Chemical Structure Class;Interferes with Protein SynthesisSpectrum of Activity;antibiotic;化合物;化工原料;试剂盒-细胞分析试剂盒;小分子;L - ZAntibiotics;Mechanism of Action;Spectrum of Activity;Signalling |
| Mol文件 | 11089-65-9.mol |
| 结构式 |  |
衣霉素 性质
| 熔点 | 234-235℃ (decomposition) |
|---|---|
| 比旋光度 | D20 +52° (c = 0.5 in pyridine) |
| 闪点 | 87℃ |
| 储存条件 | 2-8°C |
| 溶解度 | 溶于甲醇、乙醇、DMSO或DMF |
| 形态 | 白色至类白色固体 |
| 颜色 | 白色 |
| 敏感性 | Moisture & Light Sensitive |
| BRN | 6888090 |
| 稳定性 | 自购买之日起 2 年内保持稳定。 DMSO 或乙醇溶液可在 -20°C 下保存长达 1 个月。 |
| InChIKey | YJQCOFNZVFGCAF-WPTOCQRYSA-N |
| EPA化学物质信息 | Tunicamycin (11089-65-9) |
Tunicamycin (2 µg/mL; 24 hours; CD44+/CD24- and original MCF7 cells) treatment increases the spliced XBP-1, ATF6 nuclear translocation level and CHOP protein expression in CD44+/CD24- and original MCF7 cells.
Tunicamycin-induced ER stress suppresses CD44+/CD24- phenotype cell subpopulation and in vitro invasion and accelerates tumorosphore formation. Under effect of Tunicamycin, the results show that inhibited invasion, increased cell death, suppressed proliferation and reduced migration in the CD44+/CD24- and CD44+/CD24- rich MCF7 cell culture.
Western Blot Analysis
| Cell Line: | CD44+/CD24- and original MCF7 cells [1] |
| Concentration: | 2 µg/mL |
| Incubation Time: | 24 hours |
| Result: | Increased level of spliced XBP-1, ATF6 nuclear translocation and CHOP protein expression are detected in CD44+/CD24- and original MCF7 cells. |
Tunicamycin (0.1 mg/kg or 0.5 mg/kg) treatment dramatically suppresses tumor growth in the CD133 +/- MHCC97L cells xenograft model (BALB/c ( nu/nu ) mice).
安全信息
| 危险品标志 | T+,T |
|---|---|
| 危险类别码 | 28 |
| 安全说明 | 28-37/39-45 |
| 危险品运输编号 | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | YO7980200 |
| F | 8-10-18-21 |
| 危险等级 | 6.1(a) |
| 包装类别 | II |
| 海关编码 | 29419090 |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-A0098 | 衣霉素 Tunicamycin | 11089-65-9 | 2mg | 1925元 |
| 2024/01/25 | HY-A0098 | 衣霉素 Tunicamycin | 11089-65-9 | 5mg | 3850元 |