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SECOBARBITAL

SECOBARBITAL Basic information
Product Name:SECOBARBITAL
Synonyms:Trisomnin;5-ALLYL-5-[1-METHYLBUTYL]BARBITURIC ACID;secobarbital free acid--dea schedule ii item;secobarbital methanol solution;SECOBARBITAL 98+%;secobarbital solution;5-ALLYL-5-(1-METHYLBUTYL)BARBITURICACID(SECOBARBITAL);(RS)-Secobarbital
CAS:76-73-3
MF:C12H18N2O3
MW:238.28
EINECS:200-982-2
Product Categories:Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;BarbituratesAlphabetic;SA - SMForensic and Veterinary Standards;Chemical Structure;Drugs of Abuse;Drugs&Metabolites;S;Solutions
Mol File:76-73-3.mol
SECOBARBITAL Structure
SECOBARBITAL Chemical Properties
Melting point 98°C
Boiling point 380.88°C (rough estimate)
density 1.1343 (rough estimate)
refractive index 1.4760 (estimate)
Fp 11 °C
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
pka7.81±0.10(Predicted)
Water Solubility 1.728g/L(24 ºC)
EPA Substance Registry System2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylbutyl)-5-(2-propen-1-yl)- (76-73-3)
Safety Information
Hazard Codes F,T
Risk Statements 11-23/24/25-39/23/24/25-36/37/38-25
Safety Statements 36/37-45-26-16
RIDADR UN 1230 3/PG 2
WGK Germany 2
RTECS CP9450000
HazardClass 6.1(b)
PackingGroup III
HS Code 2933530000
Hazardous Substances Data76-73-3(Hazardous Substances Data)
ToxicityA barbiturate sedative-hypnotic with a long half-life, the abuse of which can lead to tolerance and dependence. The oral LD50 in rats is 125 mg/kg.
MSDS Information
ProviderLanguage
SigmaAldrich English
SECOBARBITAL Usage And Synthesis
DescriptionSecobarbital (CRM) (Item No. 21707) is a certified reference material categorized as a barbiturate. It extends intoxication and increases withdrawal effects in patients with a family history of alcoholism. Secobarbital is regulated as a Schedule II compound in the United States. Secobarbital (CRM) (Item No. 21707) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
UsesBarbiturates are being widely used as antiepileptics, hypnotics, and anesthetics Controlled substance.
DefinitionChEBI: A member of the class of barbiturates that is barbituric acid in which the hydrogens at position 5 are substituted by prop-2-en-1-yl and pentan-2-yl groups.
Brand nameSeconal(Lilly);Seconal sodium;Tuinal.
World Health Organization (WHO)Secobarbital is a short to intermediate-acting barbiturate which is controlled under Schedule III of the 1971 Convention on Psychotropic Substances. See WHO comment for barbiturates. (Reference: (UNCPS3) United Nations Convention on Psychotropic Substances (III), , , 1971)
Purification MethodsIt is purified by dissolving the sodium salt [309-43-3] in 10% HCl which precipitates the acid form that is extracted into Et2O. The extract is dried (Na2SO4) and evaporated. The residue is then purified by repeated crystallisation from CHCl3. [Buchet & Sandorfy J Phys Chem 88 3274 1984, Beilstein 24 III/IV 2013.]
SECOBARBITAL Preparation Products And Raw materials
Raw materialsAllyl bromide
Tag:SECOBARBITAL(76-73-3) Related Product Information
SECOBARBITAL (RS)-Secobarbital sodium,secobarbital natrium,SECOBARBITAL SODIUM >96% SEDATIVE, HYPNO TIC,SECOBARBITAL SODIUM SALT SECOBARBITAL-D5,100/MLINMETHANOL,SECOBARBITAL-D5 (ALLYL-D5),SECOBARBITAL-D5 SECOBARBITAL-D5,SECOBARBITAL-D5 (ALLYL-D5),secobarbital-D5 methanol solution,secobarbital-D5--dea schedule ii item Barbituric acid BARBITAL SECOBARBITAL UNLABELED 1.0 MG/ML IN METHANOL ANTI-SECOBARBITAL,ANTI-BARBITURATE (SECOBARBITAL) SECOBARBITAL HRP SECOBARBITAL-D5 (1-METHYL-D3; BUTYL-2,2-D2) - CONTROLLED S(-)-Secobarbital (R)-(+)-Secobarbital SECOBARBITAL BSA SECOBARBITAL-D5 (1-METHYL-D3, BUTYL-2,2-D2) R(+)-Secobarbital sodium S(-)-Secobarbital,S(-)-Secobarbital sodium SECOBARBITAL,1.0MG/MLINMETHANOL SECOBARBITAL-13C4 (1MG/MLMETHANOL SOLN)