7(R)-Maresin 1
| 中文名称 | 7(R)-Maresin 1 |
|---|---|
| 中文同义词 | |
| 英文名称 | 7(R)-Maresin 1 |
| 英文同义词 | 7(R)-Maresin 1;Maresin 1;7(R)-Maresin 1 Exclusive;HLHYXXBCQOUTGK-FHCQLJOMSA-N;4,8,10,12,16,19-Docosahexaenoic acid, 7,14-dihydroxy-, (4Z,7R,8E,10E,12Z,14S,16Z,19Z)- |
| CAS号 | 1268720-28-0 |
| 分子式 | C22H32O4 |
| 分子量 | 360.49 |
| EINECS号 | |
| 相关类别 | 生化试剂 |
| Mol文件 | 1268720-28-0.mol |
| 结构式 |  |
7(R)-Maresin 1 性质
| 沸点 | 559.4±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.048±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -80°C, protect from light |
| 溶解度 | DMF：50mg/mL； DMSO：50mg/mL；乙醇：50mg/mL； PBS（pH 7.2）：0.05 mg/mL |
| 酸度系数(pKa) | 4.58±0.10(Predicted) |
Maresin 1 是人体内源性的 DHA 产生的 特异性调节介质，可以刺激胞内Ca2+ 产生和分泌。Maresin 1 具有抗炎活性。
Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production.
Cell Viability Assay
| Cell Line: | Neutrophils (2 ╳10 5 cells/well). |
| Concentration: | 300 nM. |
| Incubation Time: | 30 min. |
| Result: | Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well [3] . |
Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC
50
=0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice.
Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis.
| Animal Model: | Male CD1 mice (8-10 wk of age) (colitis was induced by DSS). |
| Dosage: | 0.1, 0.3, and 1 μg/animal. |
| Administration: | Intraocular route once a day from day 0 to day 7. |
| Result: |
MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.
|
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-116429 | Maresin 1 | 10 μg (277.4 μM * 100 μL in Ethanol) | 2500元 | |
| 2024/04/30 | HY-116429 | 7(R)-Maresin 1 Maresin 1 | 1268720-28-0 | 25μg(277.4μM * 250μL in Ethanol) | 5000元 |