JNK INHIBITOR V CALBIOCHEM
中文名称 | JNK INHIBITOR V CALBIOCHEM |
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中文同义词 | AS601245.TFA盐;ALPHA-[2-[[2-(3-吡啶基)乙基]氨基]-4-嘧啶基]-2-苯并噻唑乙腈;JNK抑制剂(AS601245);2-(苯并[D]噻唑-2-基)-2-(2-((2-(吡啶-3-基)乙基)氨基)嘧啶-4-基)乙腈;化合物AS601245;JNK INHIBITOR V CALBIOCHEM;AS601245,ATP竞争性JNK抑制剂 |
英文名称 | AS601245 |
英文同义词 | AS601245;AS601245.TFA;JNK Inhibitor V;alpha-[2-[[2-(3-Pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile;2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile;2-Benzothiazoleacetonitrile, α-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-;CS-1619;2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile |
CAS号 | 345987-15-7 |
分子式 | C20H16N6S |
分子量 | 372.45 |
EINECS号 | |
相关类别 | 小分子抑制剂;小分子抑制剂,天然产物;细胞生物学试剂;Inhibitors |
Mol文件 | 345987-15-7.mol |
结构式 |
JNK INHIBITOR V CALBIOCHEM 性质
沸点 | 635.6±65.0 °C(Predicted) |
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密度 | 1.366±0.06 g/cm3(Predicted) |
储存条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
溶解度 | 不溶于水;不溶于乙醇; ≥14.25 mg/mL,溶于 DMSO |
酸度系数(pKa) | 5.32±0.10(Predicted) |
形态 | 白色至黄色固体 |
hJNK1 150 nM (IC 50 ) |
hJNK2 220 nM (IC 50 ) |
hJNK3 70 nM (IC 50 ) |
AS601245, an anti-Inflammatory JNK inhibitor, and Clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells .
AS601245 (40, 60, and 80 mg/kg; i.p.) provides significant protection against the delayed loss of hippocampal CA1 neurons in a gerbil model of transient global ischemia.
AS601245 (0.3-10 mg/kg; p.o.) is a potent inhibitor of LPS-induced TNF-α release in mice.
Animal Model: | C3H/HEN mice |
Dosage: | 0.3, 1, 3, or 10 mg/kg |
Administration: | P.o. |
Result: | Decreased the TNF-α release in a dose-dependent manner. |
安全信息
海关编码 | 2922500090 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-11010 | AS601245 | 1 mg | 545元 | |
2024/01/25 | HY-11010 | AS601245 | 345987-15-7 | 5mg | 1200元 |