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| | BMS 833923 Basic information |
| Product Name: | BMS 833923 | | Synonyms: | BMS 833923;XL 139;XL139;XL-139;BMS-833923 (XL-139);N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide;Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-;BMS 833923 N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide | | CAS: | 1059734-66-5 | | MF: | C30H27N5O | | MW: | 473.57 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1059734-66-5.mol |  |
| | BMS 833923 Chemical Properties |
| density | 1.252±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≥47.4 mg/mL in DMSO; insoluble in H2O; ≥5.14 mg/mL in EtOH with gentle warming and ultrasonic | | form | solid | | pka | 13.42±0.70(Predicted) |
| | BMS 833923 Usage And Synthesis |
| Description | Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models. | | Uses | BMS 833923 is an antagonist of smoothened, a key hedgehog (Hh) pathway regulator. |
| | BMS 833923 Preparation Products And Raw materials |
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