EXHERIN
中文名称 | EXHERIN |
---|---|
中文同义词 | 化合物EXHERIN TRIFLUOROACETATE;ADH-1三氟乙酸盐 |
英文名称 | Exherin (trifluoroacetate) |
英文同义词 | Exherin (trifluoroacetate);ADH-1 trifluroacetate;ADH-1 TRIFLUOROACETATE;ADH 1,ADH1 trifluoroacetate,Inhibitor,ADH1,ADH-1,inhibit,ADH 1 trifluoroacetate |
CAS号 | 1135237-88-5 |
分子式 | C24H35F3N8O8S2 |
分子量 | 684.7087096 |
EINECS号 | |
相关类别 | 环肽;抑制剂;多肽 |
Mol文件 | 1135237-88-5.mol |
结构式 |
EXHERIN 性质
储存条件 | Store at -20°C |
---|---|
溶解度 | DMSO:43.0(最大浓度 mg/mL);62.8(最大浓度 mM) |
ADH-1 (0.2 mg/mL) blocks collagen I-mediated changes in pancreatic cancer cells, and is highly effective at preventing cell motility that is induced by expression of N-cadherin. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner.
ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells. ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model. ADH-1 (10 mL/kg, i.p.) augmentation of melanoma tumor growth is overcome through its ability to make regionally infused melphalan more effective. ADH-1 mediated augmentation of melanoma tumor growth is not altered by regionally infused temozolomide. In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/01/25 | HY-13541A | EXHERIN ADH-1 trifluoroacetate | 1135237-88-5 | 5mg | 1100元 |
2024/01/25 | HY-13541A | EXHERIN ADH-1 trifluoroacetate | 1135237-88-5 | 10mM * 1mLin DMSO | 1657元 |