ML346
| 中文名称 | ML346 |
|---|---|
| 中文同义词 | 5-[3-(4-甲氧基苯基)-2-丙烯-1-基]-2,4,6(1H,3H,5H)-嘧啶三酮;HSP70激动剂(ML346);化合物ML346;5-(3-(4-甲氧基苯基)烯丙基亚基)嘧啶-2,4,6(1H,3H,5H)-三酮 |
| 英文名称 | ML346 |
| 英文同义词 | ML346;ML346;ML 346;ML346 - CID 767276;CS-2056;2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-;5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione;response,inhibit,probe,protein,Heat shock proteins,Inhibitor,ML346,ML 346,HSP,shock,conformational,cytotoxicity,ML-346,heat,chaperones |
| CAS号 | 100872-83-1 |
| 分子式 | C14H12N2O4 |
| 分子量 | 272.26 |
| EINECS号 | 604-604-1 |
| 相关类别 | 细胞生物学试剂;对照品 |
| Mol文件 | 100872-83-1.mol |
| 结构式 |  |
ML346 性质
| 熔点 | 266-268 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| 密度 | 1.374±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO溶解度：8.0(最大浓度 mg/mL);29.38(最大浓度 mM) |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 7.42±0.20(Predicted) |
| Target | Value |
|
HSP70
() |
ML346 is an activator of Hsp70, with an EC 50 of 4600 nM in HeLa cells. ML346 (10 μM) restores proteostasis, restores CFTR-mediated iodide conductance, and enhances the correct folding of proteins expressed in two different cellular compartments. ML346 (Compound F1) induces multiple responses and strongly induces Hsp70, the oxidative stress response genes (HO1 and GCLM), and a 2.5-fold upregulation of BiP in WT MEF cells. ML346 (0.5-25 μM) exhibits cytoprotective effects in cells after a 35 min severe heat shock, and also causes a two-fold protection from H 2 O 2 -induced apoptosis.
ML346 suppress the aggregation of polyQ35 in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-18669 | ML346 ML346 | 100872-83-1 | 2mg | 600元 |
| 2024/01/25 | HY-18669 | ML346 ML346 | 100872-83-1 | 10mM * 1mLin DMSO | 898元 |