1982372-88-2
中文名称 | 1982372-88-2 |
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中文同义词 | SUV420H1和SUV420H2化学抑制剂(A-196);A-196游离态;化合物A196;6,7-二氯-N-环戊基-4-(吡啶-4-基)酞嗪-1-胺;A 196,SUV420H1 / H2抑制剂 |
英文名称 | A-196 |
英文同义词 | A-196;6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine;SGC A-196;1-Phthalazinamine, 6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)-;6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine;A-196 (A196;A-196;A 196;A196;A196,Histone Methyltransferase,A-196,Inhibitor,inhibit |
CAS号 | 1982372-88-2 |
分子式 | C18H16Cl2N4 |
分子量 | 359.25 |
EINECS号 | |
相关类别 | 细胞生物学试剂;对照品 |
Mol文件 | 1982372-88-2.mol |
结构式 |
1982372-88-2 性质
沸点 | 584.6±45.0 °C(Predicted) |
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密度 | 1.399±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 溶于DMSO(高达5mg/ml) |
酸度系数(pKa) | 3.96±0.30(Predicted) |
形态 | 粉末 |
颜色 | 白色至浅棕色 |
稳定性 | 可在-20°C下的DMSO或乙醇溶液保存长达2个月。 |
IC50: 25 nM (SUV420H1) and 144 nM (SUV420H2).
A-196 (0-5 μM; 48 hours; U2OS cells) treatment results in an increase in H4K20me1 (
EC
50
value of 735 nM) and a decrease in both H4K20me2 and H4K20me3 (
EC
50
values of 262 and 370 nM, respectively).
A-196 (10 μM; 72 hours; Wild-type, Suv4-20h double knockout and inhibitortreated mouse embryonic fibroblast cells) inhibits both SUV4-20 enzymes in cells in multiple tissue types without overt toxicity.
Western Blot Analysis
Cell Line: | U2OS cells |
Concentration: | 0 μM, 0.075 μM, 0.15 μM, 0.3 μM, 0.6 μM, 1.25 μM, 2.5 μM, 5 μM |
Incubation Time: | 48 hours |
Result: | Increased in H4K20me1 and decreased in both H4K20me2 and H4K20me3. |
安全信息
危险品运输编号 | UN 2811 6.1 / PGIII |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-100201 | A-196 | 1 mg | 500元 | |
2024/08/19 | HY-100201 | 1982372-88-2 A-196 | 1982372-88-2 | 10mM * 1mLin DMSO | 869元 |