FMOC-N-甲基-三聚乙二醇-丙酸
中文名称 | FMOC-N-甲基-三聚乙二醇-丙酸 |
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中文同义词 | FMOC-N-甲基-三聚乙二醇-丙酸;FMOC-N-甲基-三聚乙二醇-丙羧酸;FMOC-N-甲基-三聚乙二醇-羧酸 |
英文名称 | Fmoc-N-methyl-N-amido-PEG2-acid |
英文同义词 | Fmoc-N-methyl-N-amido-PEG2-acid;Fmoc-N-methyl-N-amido-PEG2-COOH;Fmoc-NMe-PEG2-acid;Fmoc-N-methyl-PEG3-CH2CH2COOH;5,8,11-Trioxa-2-azatetradecanedioic acid, 2-methyl-, 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-NMe-PEG3-acid;Fmoc-MeN-PEG3-CH2CH2COOH |
CAS号 | 1807518-77-9 |
分子式 | C25H31NO7 |
分子量 | 457.52 |
EINECS号 | |
相关类别 | |
Mol文件 | 1807518-77-9.mol |
结构式 |
FMOC-N-甲基-三聚乙二醇-丙酸 性质
沸点 | 630.5±55.0 °C(Predicted) |
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密度 | 1.218±0.06 g/cm3(Predicted) |
溶解度 | 溶于DMSO、DCM、DMF |
酸度系数(pKa) | 4.28±0.10(Predicted) |
Cleavable
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Alkyl/ether
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PEGs
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ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.