(R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
| 中文名称 | (R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 |
|---|---|
| 中文同义词 | (R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸;(R)-(+)-6-羟基-2,5,7,8-四甲基色烷-2-羧酸;(R)-(+)-6-羟基-2,5,7,8-四甲基没-2-羧酸;化合物 T12645;(R)-6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-羧酸;化合物 (R)-TROLOX;化合物:(R)-Trolox CAS:53101-49-8;化合物：(R)-Trolox CAS:53101-49-8 |
| 英文名称 | (R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID |
| 英文同义词 | (R)-(+)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-C;(2R)-2,5,7,8-Tetramethyl-6-hydroxychroman-2-carboxylic acid;(R)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid;(R)-Trolox;(R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 98%;(2R)-6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid;(R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID;Trolox (R)-Isomer |
| CAS号 | 53101-49-8 |
| 分子式 | C14H18O4 |
| 分子量 | 250.29 |
| EINECS号 | |
| 相关类别 | Benzopyrans;Chiral Building Blocks;Heterocyclic Building Blocks |
| Mol文件 | 53101-49-8.mol |
| 结构式 |  |
(R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 性质
| 熔点 | 162 °C (dec.) (lit.) |
|---|---|
| 沸点 | 450.3±45.0 °C(Predicted) |
| 密度 | 1.219±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（998.84 mM） |
| 酸度系数(pKa) | 3.35±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 旋光度 (Optical Rotation) | [α]27/D +65°, c = 1.2 in ethanol |
| InChI | 1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)/t14-/m1/s1 |
| InChIKey | GLEVLJDDWXEYCO-CQSZACIVSA-N |
| SMILES | Cc1c(C)c2O[C@](C)(CCc2c(C)c1O)C(O)=O |
(R)-Trolox 是水溶性维生素 E 类似物，是一种竞争性酪氨酸酶抑制剂，Ki 值为 0.83 mM，ID50 值为 1.88 mM。(R)-Trolox 具有比 (S) 对映异构体更强的酪氨酸酶亲和力 (Ki 值为 0.61 mM)。
As compared to the control containing no inhibitor, DMSO suppresses the tyrosinase activity at tested levels, 100 and 200 µL in a total volume of 3.0 mL. The inhibition of DMSO on the mushroom tyrosinase is dosedependent. Additions of DMSO at the two levels in the tyrosinase digests containing (R)-Trolox ((R)-HTCCA) results in further inhibitions of the tyrosinase activity. The influence of the DMSO on the inhibitory effects of (R)-Trolox against the tyrosinase is also dose-dependent.
安全信息
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-101445A | (R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 (R)-Trolox | 53101-49-8 | 50mg | 510元 |
| 2025/12/22 | HY-101445A | (R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 (R)-Trolox | 53101-49-8 | 10mM * 1mLin DMSO | 561元 |