ICA
中文名称 | ICA |
---|---|
中文同义词 | |
英文名称 | ICA |
英文同义词 | N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine;2-Pyridinamine, N-[4-(2-pyridinyl)-2-thiazolyl]-;2-Pyridinamine, N-[4-(2-pyridinyl) |
CAS号 | 3374-88-7 |
分子式 | C13H10N4S |
分子量 | 254.31 |
EINECS号 | |
相关类别 | |
Mol文件 | 3374-88-7.mol |
结构式 |
ICA 性质
沸点 | 466.4±48.0 °C(Predicted) |
---|---|
密度 | 1.339±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:≥ 49.5 mg/mL(194.64 mM) |
酸度系数(pKa) | 3.20±0.10(Predicted) |
形态 | 固体 |
颜色 | 浅棕色至棕色 |
IC50: 2.1 µM (Antileishmanial)
The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters.